Publications by authors named "Yu-fang Qiao"
Zhonghua Yi Xue Za Zhi
November 2008
Article Synopsis
- The study aimed to create RNAi recombinant adenoviral vectors to specifically target and reduce the expression of GSK-3beta, a gene that plays a critical role in cell proliferation, and to analyze the influence of the Wnt/beta-catenin signaling pathway on the growth of human thyroid cells.
- Researchers constructed an adenovirus plasmid with RNAi targeting GSK-3beta, transfected it into HEK293A cells, and then tested its ability to knock down this gene in normal human thyrocytes, assessing its impact on cell proliferation and beta-catenin levels.
- Results showed that the GSK-3beta gene was significantly silenced in infected thyro
