Publications by authors named "Yu-chun Li"

Wide-bandgap (WBG) semiconductors are at the forefront of driving innovations in electronic technology, perpetuating Moore's Law and opening up new avenues for electronic devices. Although β-GaO has attracted extensive research interest in advanced electronics, its high-temperature and high-speed volatile memory applications in harsh environment has been largely overlooked. Herein, a high-performance hexagonal boron nitride (h-BN)/β-GaO heterostructure junction field-effect transistor (HJFET) is fabricated, exhibiting an off-state current as low as ≈10 fA, a high on/off current ratio of ≈10, a low contact resistance of 5.

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Numerous studies have shown that hyperlipidaemia is closely related to the gut microbiota, and the study of microbiota in the treatment of hyperlipidaemia is undoubtedly a new target for the treatment and prevention of hyperlipidaemia. The efficacy of regulating the gut microecology and changing the structure of gut flora has been demonstrated by both western and traditional medication, biological therapy, and dietary exercise, so it is particularly important to study the relationship between gut microbiota and the treatment of hyperlipidaemia. In this review, we summarize the mechanism and relationship between the pathogenesis of hyperlipidaemia and gut microbiota, and the mechanism of hyperlipidaemia treatment by influencing the gut microbiota in various treatment modalities, which provides diversified therapeutic ideas and scientific basis for clinical treatment.

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  • - The study analyzed 94 patients with acute ischemic stroke to determine how serum inflammatory factors, specifically IL-6 and TNF-α, impact prognosis after revascularization therapy.
  • - Patients were divided into good (mRS ≤ 2) and poor (mRS > 2) prognosis groups, with those in the good prognosis group showing lower levels of inflammatory markers and better clinical scores at admission.
  • - The findings suggest IL-6 and TNF-α could be useful indicators for predicting recovery outcomes in stroke patients post-treatment, indicating that those with higher levels may have worse prognoses.
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Adaptation to high-altitude hypoxia is characterized by systemic and organ-specific metabolic changes. This study investigates whether intestinal metabolic rewiring is a contributing factor to hypoxia adaptation. We conducted a longitudinal analysis over 108 days, with seven time points, examining fecal metabolomic data from a cohort of 46 healthy male adults traveling from Chongqing (a.

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The employment of ultra-low permittivity materials in the configuration of antennas has been demonstrated to augment the antenna bandwidth and diminish signal delay effectively. This study presents three ultra-low permittivity metaphosphate microwave dielectric ceramics (MWDCs). The ALaPO (A = Li, Na, K) metaphosphate ceramics, which all belong to the monoclinic crystal system, exhibit extremely low permittivity (ε ≈ 5) and excellent quality factor (· > 10,000 GHz) at a low sintering temperature ( < 950 °C).

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Background: Investigating oncogenes and the mechanisms driving oncogenic processes in human tumors is imperative for the development of efficient therapies. Peroxidasin (PXDN) has been reported to play a critical role in tissue development and homeostasis. However, the role of PXDN in the occurrence and development of Nasopharyngeal Carcinoma (NPC) remains unknown.

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  • Scientists are studying how the bacteria in our gut react when people go to high places where there’s less oxygen, like mountains.
  • They took a long look at 45 healthy people who traveled from a low area to a high plateau for 108 days and found that their gut bacteria changed a lot, especially a type called Blautia A.
  • The study suggests Blautia A could help keep our guts healthy and help people adapt to living in places with less oxygen.
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The gallium-doped hafnium oxide (Ga-HfO) films with different Ga doping concentrations were prepared by adjusting the HfO/GaO atomic layer deposition cycle ratio for high-speed and low-voltage operation in HfO-based ferroelectric memory. The Ga-HfO ferroelectric films reveal a finely modulated coercive field () from 1.1 (HfO/GaO = 32:1) to an exceptionally low 0.

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  • * Al-doped hafnium oxide (HfAl) has been proposed as a dielectric layer to address these issues because of its higher crystallization temperature and better dielectric properties.
  • * The newly developed MoS phototransistor with HfAlO shows impressive performance metrics, including high responsivity, detectivity, and efficiency, indicating its potential for future optoelectronic applications.
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  • Widespread species tend to have larger populations and better environmental adaptability, enabling them to expand their ranges, whereas narrow-range species are limited to specific areas and conditions.
  • The study uses a species complex of wild rats in Southeast Asia and China to analyze the genomic differences between widespread and narrow-range species, finding that the former exhibit higher genetic diversity.
  • The researchers identified 13 specific genes related to nervous system development that are shared among the widespread species, suggesting these genes are important for their adaptive evolution and speciation.
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Although it is widely recognized that the ancestors of Native Americans (NAs) primarily came from Siberia, the link between mitochondrial DNA (mtDNA) lineage D4h3a (typical of NAs) and D4h3b (found so far only in East China and Thailand) raises the possibility that the ancestral sources for early NAs were more variegated than hypothesized. Here, we analyze 216 contemporary (including 106 newly sequenced) D4h mitogenomes and 39 previously reported ancient D4h data. The results reveal two radiation events of D4h in northern coastal China, one during the Last Glacial Maximum and the other within the last deglaciation, which facilitated the dispersals of D4h sub-branches to different areas including the Americas and the Japanese archipelago.

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The family of Papilionidae (Lepidoptera: Papilionoidea) is a group of butterflies with high ecological and conservation value. The Hengduan Mountains (HMDs) in Southwest China is an important diversity centre for these butterflies. However, the spatial distribution pattern and the climate vulnerability of Papilionidae butterflies in the HDMs remain unknown to date.

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  • Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition linked to an imbalance in gut bacteria, and Zhishi Daozhi Decoction (ZDD) is derived from traditional Chinese medicine with potential liver-protecting benefits.!* -
  • In a study, mice fed a high-fat diet were given ZDD, resulting in reduced body weight, lower liver and blood lipid levels, decreased liver fat accumulation, and improved intestinal flora composition.!* -
  • The findings suggest that ZDD might help treat NAFLD by enhancing gut health and promoting a better environment for intestinal bacteria, along with bolstering the expression of proteins that maintain intestinal structure.!*
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Background: This study aimed to explore the relationship between serum netrin-1 expression levels and acute prognosis in patients with acute ischemic stroke (AIS) within 24 hours after revascularization.

Methods: A total of 121 revascularized patients admitted to the Jinshan Branch of the Shanghai Sixth People's Hospital, China, between July 2019 and July 2021 were selected as study subjects. The primary outcome was the modified Rankin Scale (mRS) score three months after revascularization: patients with an mRS score >2 were classified into the unfavorable prognosis group and others into the favorable prognosis group.

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β-GaO is considered an attractive candidate for next-generation high-power electronics due to its large band gap of 4.9 eV and high breakdown electrical field of 8 MV/cm. However, the relatively low carrier concentration and low electron mobility in the β-GaO-based device limit its application.

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The superior optical and electronic characteristics of quasi-two-dimensional β-GaO make it suitable for solar-blind (200-280 nm) photodetectors (PDs). The metal-semiconductor-metal (MSM) PDs commonly suffer from low photoresponsivity, slow response speed, and a narrow detection wavelength range despite their simple fabrication process. Herein, we report a high-performance MSM PD by integrating exfoliated β-GaO flakes with zero-dimensional graphene quantum dots (GQDs), which exhibits the advantages of enhancing the photoresponsivity, shortening the photoresponse time, and stimulating a broad range of photon detection.

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  • A high-performing ReS/ReSe van der Waals heterojunction phototransistor was developed using a thin layer of hafnium oxide as a dielectric.
  • The device demonstrated exceptional electrical characteristics, including a rectification ratio of approximately 10, an ultra-low off-state current of 433 fA, and a significant on/off current ratio exceeding 10.
  • Strong photodetection capabilities were observed with a responsivity around 10 A/W and a peak detectivity of 1.8 × 10^10 Jones at 633 nm, mainly due to effective band alignment and dark current suppression from the local-back-gate.
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To elucidate whether Bronze Age population dispersals from the Eurasian Steppe to South Asia contributed to the gene pool of Indo-Iranian-speaking groups, we analyzed 19,568 mitochondrial DNA (mtDNA) sequences from northern Pakistani and surrounding populations, including 213 newly generated mitochondrial genomes (mitogenomes) from Iranian and Dardic groups, both speakers from the ancient Indo-Iranian branch in northern Pakistan. Our results showed that 23% of mtDNA lineages with west Eurasian origin arose in situ in northern Pakistan since ~5000 years ago (kya), a time depth very close to the documented Indo-European dispersals into South Asia during the Bronze Age. Together with ancient mitogenomes from western Eurasia since the Neolithic, we identified five haplogroups (~8.

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An asymmetric dual-gate (DG) MoSfield-effect transistor (FET) with ultrahigh electrical performance and optical responsivity using atomic-layer-deposited HfOas a top-gate (TG) dielectric was fabricated and investigated. The effective DG modulation of the MoSFET exhibited an outstanding electrical performance with a high on/off current ratio of 6 × 10. Furthermore, a large threshold voltage modulation could be obtained from -20.

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  • The Fujian Tanka people are officially recognized as a southern Han ethnic group but share customs with Daic and Austronesian cultures, leading to debates on their origins.
  • Three hypotheses regarding their origins include descent from Han Chinese, ancient Daic peoples, or a mix between the two.
  • Genetic analysis shows that the Tanka have closer paternal lineage ties to Daic populations while sharing maternal lineages with southern Han, supporting the idea that they mainly descend from indigenous Daic people with limited Han influence.
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With a population of around 4 000 individuals, the Kalash people have been living in the Hindu-Kush mountain valleys of present-day northern Pakistan for centuries. Due to their mysterious origin and fairer European complexion, the genetic history of this ethnic group has been investigated previously using different markers. To date, however, the maternal genetic architecture has not been systematically dissected based on high-resolution complete mitochondrial genomes (mitogenomes), making their maternal genetic history, especially their genetic connection with Europeans from a matrilineal perspective, unclear.

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The permanent human settlement of the Tibetan Plateau (TP) has been suggested to have been facilitated by the introduction of barley agriculture ∼3.6 kilo-years ago (ka). However, how barley agriculture spread onto the TP remains unknown.

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A general south-north genetic divergence has been observed among Han Chinese in previous studies. However, these studies, especially those on mitochondrial DNA (mtDNA), are based either on partial mtDNA sequences or on limited samples. Given that Han Chinese comprise the world's largest population and reside around the whole China, whether the north-south divergence can be observed after all regional populations are considered remains unknown.

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A palladium-catalyzed ring-opening oxo-formal [3 + 2]-cycloaddition reaction of novel donor-acceptor spirovinylcyclopropyl oxindole with 3-oxindole is described. The developed protocol provides facile access to oxo-bispirooxindole derivatives in good yields (up to 82% yield) with excellent diastereoselectivities (up to 20:1 dr).

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