Publications by authors named "Yu-cheng Sheng"

Purpose: As HF progresses into advanced HF, patients experience a poor quality of life, distressing symptoms, intensive care use, social distress, and eventual hospital death. We aimed to investigate the relationship between morality and potential prognostic factors among in-patient and emergency patients with HF.

Patients And Methods: A case series study: Data are collected from in-hospital and emergency care patients from 2014 to 2021, including their international classification of disease at admission, and laboratory data such as blood count, liver and renal functions, lipid profile, and other biochemistry from the hospital's electrical medical records.

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Chronic kidney disease (CKD) is a major public health concern. But there are limited machine learning studies on non-cancer patients with advanced CKD, and the results of machine learning studies on cancer patients with CKD may not apply directly on non-cancer patients. We aimed to conduct a comprehensive investigation of risk factors for a 3-year risk of death among non-cancer advanced CKD patients with an estimated glomerular filtration rate < 60.

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Metabolic syndrome (MetS) includes several conditions that can increase an individual's predisposition to high-risk cardiovascular events, morbidity, and mortality. Non-alcoholic fatty liver disease (NAFLD) is a predominant cause of cirrhosis, which is a global indicator of liver transplantation and is considered the hepatic manifestation of MetS. FibroScan provides an accurate and non-invasive method for assessing liver steatosis and fibrosis in patients with NAFLD, via a controlled attenuation parameter (CAP) and liver stiffness measurement (LSM or E) scores and has been widely used in current clinical practice.

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Transient elastography or elastometry (TE) is widely used for clinically cirrhosis and liver steatosis examination. Liver fibrosis and fatty liver had been known to share some co-morbidities that may result in chronic impairment in renal function. We conducted a study to analyze the association between scores of 2 TE parameters, liver stiffness measurement (LSM) and controlled attenuation parameter (CAP), with chronic kidney disease among health checkup population.

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Objective: End-stage liver disease is a global public health problem with a high mortality rate. Early identification of people at risk of poor prognosis is fundamental for decision-making in clinical settings. This study created a machine learning prediction system that provides several related models with visualized graphs, including decision trees, ensemble learning and clustering, to predict mortality in patients with end-stage liver disease.

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Background: More than 79.2 million confirmed COVID-19 cases and 1.7 million deaths were caused by SARS-CoV-2; the disease was named COVID-19 by the World Health Organization.

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A third of the world's population is classified as having Metabolic Syndrome (MetS). Traditional diagnostic criteria for MetS are based on three or more of five components. However, the outcomes of patients with different combinations of specific metabolic components are undefined.

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Background: Patients with end-stage liver disease (ESLD) have limited treatment options and have a deteriorated quality of life with an uncertain prognosis. Early identification of ESLD patients with a poor prognosis is valuable, especially for palliative care. However, it is difficult to predict ESLD patients that require either acute care or palliative care.

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Article Synopsis
  • The study explores how machine learning can improve medical informatics by creating a database system from electronic medical records (EMRs) to help with online self-health evaluation for both clinicians and patients.
  • The developed prediction models demonstrated high accuracy, with a 91% accuracy rate for metabolic syndrome and 94.7% for chronic kidney disease, alongside effective visualizations to enhance user understanding.
  • The web-based system facilitates access to online diagnosis predictions and health reports, promoting awareness of personal health status and future connections with hospitals globally.
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Background: Metabolic syndrome is a cluster of disorders that significantly influence the development and deterioration of numerous diseases. FibroScan is an ultrasound device that was recently shown to predict metabolic syndrome with moderate accuracy. However, previous research regarding prediction of metabolic syndrome in subjects examined with FibroScan has been mainly based on conventional statistical models.

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Background: Preventive medicine and primary health care are essential for patients with chronic kidney disease (CKD) because the symptoms of CKD may not appear until the renal function is severely compromised. Early identification of the risk factors of CKD is critical for preventing kidney damage and adverse outcomes. Early recognition of rapid progression to advanced CKD in certain high-risk populations is vital.

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Terminal disinfection and daily cleaning have been performed in hospitals in Taiwan for many years to reduce the risks of healthcare-associated infections. However, the effectiveness of these cleaning approaches and dynamic changes of surface microbiota upon cleaning remain unclear. Here, we report the surface changes of bacterial communities with terminal disinfection and daily cleaning in a medical intensive care unit (MICU) and only terminal disinfection in a respiratory care center (RCC) using 16s ribosomal RNA (rRNA) metagenomics.

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  • * A total of 144 patients who underwent carotid artery stenting were analyzed, with measures like the modified Rankin scale (mRS) and Barthel index (BI) used to evaluate their physical functionality before and after the procedure.
  • * Results showed that key prestenting factors such as cerebral blood volume ratio and BI differed significantly between patients who improved versus those who did not; however, age was not significantly associated with poststenting outcomes, indicating that stenting can benefit elderly patients similarly to
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Carotid artery stenting is an effective treatment for ischemic stroke patients with moderate-to-severe carotid artery stenosis. However, the midterm outcome for patients undergoing this procedure varies considerably with baseline characteristics. To determine the impact of baseline characteristics on outcomes following carotid artery stenting, data from 107 eligible patients with a first episode of ischemic stroke were collected by retrospective chart review.

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Carotid stenting is an effective treatment of choice in terms of treating ischemic stroke patients with concomitant carotid stenosis. Though computed tomography perfusion scan has been recognized as a standard tool to monitor/follow up this group of patients, not everyone could endure due to underlying medical illness. In contrast, carotid duplex is a noninvasive assessment tool and could track patient clinical condition in real time.

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The purpose of this study was to use the stochastic simulation and estimation method to evaluate the effects of sample size and the number of samples per individual on the model development and evaluation. The pharmacokinetic parameters and inter- and intra-individual variation were obtained from a population pharmacokinetic model of clinical trials of amlodipine. Stochastic simulation and estimation were performed to evaluate the efficiencies of different sparse sampling scenarios to estimate the compartment model.

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  • The study aimed to develop a new cyclic fluctuation model for analyzing 24-hour ambulatory blood pressure monitoring (ABPM) in Chinese patients with mild to moderate hypertension, addressing limitations of traditional methods.
  • Data from four clinical trials were utilized, with the cyclic fluctuation model demonstrating effectiveness in describing blood pressure patterns through the use of cosine functions and verified by statistical methods.
  • The successful application of the model across all studies enhances our understanding of blood pressure variability, which could improve drug development and personalized treatment for hypertension.
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  • - The study aims to lower the costs of sampling needed to estimate the area under the gliclazide concentration versus time curve over 60 hours (AUC0-60t) using limited sampling strategies (LSS).
  • - Multiple regression models were used to validate the effectiveness of LSS, showing that using 2, 3, or 4 concentration values improved accuracy, with 90.2% to 92.4% of models performing well enough.
  • - Key sampling times identified as most effective were at 2, 4, 6, and 12 hours post-administration, with specific combinations recommended for practical use to predict AUC0-60t accurately.
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  • * Using multiple regression analysis, the study found that most LSS models (97.5% to 100%) could predict AUC(0-24 h) accurately within a 15% error margin when using 2 to 4 concentration-time points.
  • * Key time points for sampling after drug administration identified were 12, 4, 24, and 2 hours; combinations of these may be utilized for practical applications based on specific requirements for AUC estimation.
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  • The study aimed to assess how race affects the pharmacodynamics of rosuvastatin in Western and Asian patients with high cholesterol using a population pharmacodynamic model derived from clinical trials.
  • Researchers used published randomized trials featuring rosuvastatin to build and validate their model, focusing on LDL-C reduction as a response to different doses, and included factors like race and baseline LDL-C in their analysis.
  • The findings showed a consistent dose-response relationship for rosuvastatin in both races, indicating similar effects on lowering LDL-C, which could inform future drug approvals for Asian markets based on Western clinical efficacy data.
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  • The study investigates how different CYP2C19 genetic types affect the metabolism and effectiveness of the medication rabeprazole in healthy Chinese males after a single dose.
  • Researchers analyzed plasma concentration and pH data to create a model showing that genetic variations influence the drug's clearance rates, with poor metabolizers (PM) showing the lowest clearance.
  • Findings suggest that while the standard dose of rabeprazole may work for poor metabolizers, those with other genotypes might require more frequent dosing to effectively treat conditions like gastroesophageal reflux disease.
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  • This paper introduces a new optimization technique focused on designing piezoelectric buzzers to enhance sound pressure output by improving the configuration of their components.
  • The study develops an "added-mass method" to estimate the system's electromechanical parameters, allowing for simulations of electrical impedance and sound pressure using an analogous circuit.
  • Findings reveal strong similarities between piezoelectric buzzers and dynamic vibration absorbers, leading to the creation of a design chart that helps identify the critical frequency for maximum output, ultimately resulting in significantly improved performance through optimal design experiments.
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