Publications by authors named "Yu-bao Qiu"

Article Synopsis
  • Ferroptosis is a type of cell death linked to oxidative stress, and is important in conditions like acute lung injury (ALI) caused by seawater drowning.
  • Researchers tested the role of Nrf2, a protein that can suppress ferroptosis, using various methods, including activating or inhibiting Nrf2 in cells and animal models.
  • Results showed that activating Nrf2 improved cell survival and reduced harmful ROS levels, while deactivating it worsened lung injury, suggesting that Nrf2 is a potential target for treating ALI from seawater drowning.
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Short-chain fatty acids (SCFAs), especially propionate, originate from the fermentation of dietary fiber in the gut and play a key role in inhibiting pulmonary inflammation. Chronic inflammation may induce an epithelial-mesenchymal transition (EMT) in alveolar epithelial cells and result in fibrotic disorders. This study was designed to investigate the beneficial effect of sodium propionate (SP) on lipopolysaccharide (LPS)-induced EMT.

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Article Synopsis
  • The study aimed to evaluate how curcumin protects against liver cholestasis caused by bile duct ligation (BDL) in mice, potentially offering new treatment strategies for liver fibrosis.
  • Forty-two adult male mice were divided into several groups to receive different treatments, including curcumin injections, and their liver functions and health were monitored over 14 days.
  • Results showed that curcumin significantly reduced liver damage and inflammation, indicated by lower levels of liver enzymes and collagen deposition, while increasing the expression of a protective protein (HO-1) in the liver compared to the untreated BDL group.
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Background: Hypoxia is commonly existed in tumors and lead to cancer cell chemo/radio-resistance. It is well-recognized that tumor hypoxia is a major challenge for the treatment of various solid tumors. Hyperoside (quercetin-3-O-galactoside, Hy) possesses antioxidant effects and has been reported to protect against hypoxia/reoxygenation induced injury in cardiomyocytes.

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Article Synopsis
  • Heme oxygenase-1 (HO-1) is important for protecting against acute lung injury (ALI) caused by seawater aspiration due to its anti-inflammatory, anti-oxidant, and anti-apoptotic functions.
  • Seawater exposure in A549 lung cells led to decreased survival, increased inflammation, and mitochondrial damage, while HO-1 enhancement with heme or biliverdin improved cell conditions and promoted proliferation.
  • The study demonstrated that inhibiting HO-1 using Zinc protoporphyrin reversed the protective benefits, highlighting its critical role in mitigating seawater-induced lung injury.
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Passive microwave remote sensing offers its all-weather work capabilities, but atmospheric influences on satellite microwave brightness temperature were different under different atmospheric conditions and environments. In order to clarify atmospheric influences on Advanced Microwave Scanning Radiometer-Earth Observing System (AMSR-E), atmospheric radiation were simulated based on AMSR-E configuration under clear sky and cloudy conditions, by using radiative transfer model and atmospheric conditions data. Results showed that atmospheric water vapor was the major factor for atmospheric radiation under clear sky condition.

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The microwave emissivity is a function of structure, water content, and surface roughness, and all these factors have obvious seasonal variations. In the present study, the half-month averaged emissivities in summer and winter of 2003 over the vegetation of Northern Hemisphere were estimated using Advanced Microwave Scanning Radiometer-Earth Observing System (AMSR-E) combined with IGBP (International Geosphere-Biosphere Project labels) land classification data. Then the emissivities of vegetation land covers at different frequencies, the polarization and their seasonal variations were analyzed respectively.

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The microwave emissivity over land is very important for describing the characteristics of the lands, and it is also a key factor for retrieving the parameters of land and atmosphere. Different land covers have their emission behavior as a function of structure, water content, and surface roughness. In the present study the global land surface emissivities were calculated using six month (June, 2003-August, 2003, Dec, 2003-Feb, 2004) AMSR-E L2A brightness temperature, MODIS land surface temperature and the layered atmosphere temperature, and humidity and pressure profiles data retrieved from MODIS/Aqua under clear sky conditions.

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