Publications by authors named "Yu-Zhuo Li"
Article Synopsis
- Forsythin is being tested in China for the common cold and influenza, but its effectiveness is limited due to poor solubility and lung absorption.
- Researchers created a phospholipid complex (FPC) of forsythin to enhance its lung delivery and anti-inflammatory effects, finding that it significantly improved drug dissolution and cellular uptake.
- In mouse tests, the FPC resulted in a much higher lung drug concentration and better survival rates in acute lung injury cases compared to traditional injection methods, showing promise for inhalation therapies.
Mutations in mitochondrial DNA (mtDNA) are maternally inherited and have the potential to cause severe disorders. Mitochondrial replacement therapies, including spindle, polar body, and pronuclear transfers, are promising strategies for preventing the hereditary transmission of mtDNA diseases. While pronuclear transfer has been used to generate mitochondrial replacement mouse models and human embryos, its application in non-human primates has not been previously reported.
View Article and Find Full Text PDFSynaptic control of spinal GRPR neurons by local and long-range inhibitory inputs.
Proc Natl Acad Sci U S A
December 2019
Spinal gastrin-releasing peptide receptor-expressing (GRPR) neurons play an essential role in itch signal processing. However, the circuit mechanisms underlying the modulation of spinal GRPR neurons by direct local and long-range inhibitory inputs remain elusive. Using viral tracing and electrophysiological approaches, we dissected the neural circuits underlying the inhibitory control of spinal GRPR neurons.
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