Publications by authors named "Yu-Zhuo Li"

Article Synopsis
  • Forsythin is being tested in China for the common cold and influenza, but its effectiveness is limited due to poor solubility and lung absorption.
  • Researchers created a phospholipid complex (FPC) of forsythin to enhance its lung delivery and anti-inflammatory effects, finding that it significantly improved drug dissolution and cellular uptake.
  • In mouse tests, the FPC resulted in a much higher lung drug concentration and better survival rates in acute lung injury cases compared to traditional injection methods, showing promise for inhalation therapies.
View Article and Find Full Text PDF

Mutations in mitochondrial DNA (mtDNA) are maternally inherited and have the potential to cause severe disorders. Mitochondrial replacement therapies, including spindle, polar body, and pronuclear transfers, are promising strategies for preventing the hereditary transmission of mtDNA diseases. While pronuclear transfer has been used to generate mitochondrial replacement mouse models and human embryos, its application in non-human primates has not been previously reported.

View Article and Find Full Text PDF

Spinal gastrin-releasing peptide receptor-expressing (GRPR) neurons play an essential role in itch signal processing. However, the circuit mechanisms underlying the modulation of spinal GRPR neurons by direct local and long-range inhibitory inputs remain elusive. Using viral tracing and electrophysiological approaches, we dissected the neural circuits underlying the inhibitory control of spinal GRPR neurons.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionpn7cpjpa10i8eah4demd3o0g1fi4cm9c): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once