Publications by authors named "Yu-Zhu Xu"
Article Synopsis
- Intervertebral disc degeneration (IDD) is a common cause of low back pain with limited treatment options that mainly focus on symptom relief rather than addressing the condition itself.
- * Oxidative stress, caused by an overload of reactive oxygen species (ROS), contributes significantly to the progression of IDD.
- * Polyphenols, which are natural antioxidants, may offer a potential treatment by reducing ROS, scavenging free radicals, and influencing molecular pathways involved in IDD, although there are still challenges to overcome in their application.
Objective: The purpose of the present study was to compare the clinical outcomes and complications between the mini-open Wiltse approach with pedicle screw fixation (MWPSF) and percutaneous pedicle screw fixation (PPSF) in treating neurologically intact thoracolumbar fractures.
Methods: We comprehensively searched PubMed, Web of Science, Embase, and the Cochrane Library and performed a systematic review and meta-analysis of all randomized controlled trials and retrospective comparative studies assessing these important indexes of the 2 methods using Review Manager, version 5.4.
Bone marrow mesenchymal stem cells (BMSCs) have been investigated as cellular therapeutics for intervertebral disc degeneration. However, transplanted BMSCs are prone to be damaged. TNF-α is reported to extensively promote degeneration process.
View Article and Find Full Text PDFGlomerular IgM deposition is commonly shown in idiopathic membranous nephropathy, but the clinicopathological features and outcomes of IMN with IgM deposition are unclear. This single-center prospective cohort study enrolled 210 patients with biopsy-proven IMN from January 2016 to December 2018. Clinicopathological features, treatment responses, and kidney outcomes were compared between patients with and without IgM deposition.
View Article and Find Full Text PDFObjective: The aim of this study was to determine whether obesity affects the operation, complications and outcomes after open posterior lumbar spinal fusion surgery for the treatment of low back pain and leg pain.
Methods: A meta-analysis of studies that compared the outcome of posterior lumbar spinal fusion in obese and non-obese patients. A total of 16 studies were included.