Publications by authors named "Yu-Zhou Gan"
Article Synopsis
- This study examined the clinical traits of patients with systemic lupus erythematosus (SLE) who also have autoimmune liver cirrhosis (ALC) and how they differ from SLE patients without cirrhosis.
- Out of 43 SLE-ALC patients analyzed, most were female and had notable complications like jaundice and varices, with a significantly older average age compared to the non-cirrhosis group.
- Key findings included greater liver dysfunction, elevated hematological issues, and unique radiologic signs in SLE-ALC patients, indicating that cirrhosis, while rare in SLE, presents distinct clinical features.
Article Synopsis
- - Psoriatic arthritis (PsA) is linked to psoriasis and bone damage, with Dkk-1 being a key inhibitor in the Wnt signaling pathway that affects bone health.
- - A study measured serum Dkk-1 levels in 69 PsA patients, 39 rheumatoid arthritis patients, and 21 healthy controls, revealing elevated levels in 68.1% of PsA patients compared to lower levels in healthy individuals.
- - The findings suggest that high serum Dkk-1 correlates with joint swelling and is a significant risk factor for bone erosion in PsA, indicating its potential role in the disease's pathology.
Background: Intensive therapy with disease modifying anti-rheumatic drugs (DMARDs) has been reported to improve the outcomes of rheumatoid arthritis (RA). However, real-world study on the effect of intensive therapy on RA sustained remission is still lacking. This study aimed to investigate the outcome of sustained intensive DMARD therapy (SUIT) for RA in a real-world 5-year consecutive cohort.
View Article and Find Full Text PDFRisk factors of interstitial lung diseases in clinically amyopathic dermatomyositis.
Chin Med J (Engl)
March 2020
Background: Clinically amyopathic dermatomyositis (CADM) is a unique sub-type of idiopathic inflammatory myopathies with a high prevalence of interstitial lung disease (ILD). Poor prognosis of the patients was strongly associated with rapid progressive ILD. The aim of this study was to identify risk factors for prediction of different types of ILD in CADM.
View Article and Find Full Text PDFBackground: Clinical remission is the treatment target in rheumatoid arthritis (RA). This study aimed to investigate clinical remission and related factors in a large cohort of patients with RA.
Methods: This study composed of 342 patients with RA.