Atopic dermatitis is a chronic skin condition characterized by intense itching and inflammation, but effective treatments targeting the nerve-immune interactions are limited.
Researchers examined the effects of intravenous lidocaine on both patients with atopic dermatitis and a mouse model, finding that lidocaine improved skin symptoms by blocking specific sensory neurons responsible for itch.
The study highlighted the key role of Na 1.8 sensory neurons in the disease's development and suggested that lidocaine could serve as a potential treatment for alleviating both inflammation and itch in atopic dermatitis.