Thin-film nanocomposite NF membrane with GO on macroporous hollow fiber ceramic substrate for efficient heavy metals removal.

The ceramic membrane has been widely used in the wastewater treatment based on the chemical resistance and superior separation performance. A robust and defect-free thin-film nanocomposite (TFN) nanofiltration (NF) membrane on the macroporous hollow fiber ceramic (HFC) substrate was novelly developed for heavy metals removal. Before interfacial polymerization (IP), the aqueous solution of graphene oxide (GO) grafted with ethylenediamine (EDA) was deposited on the HFC substrate by vacuum filtration.

Corrigendum: Dual-Targeting Nanoparticle-Mediated Gene Therapy Strategy for Hepatocellular Carcinoma by Delivering Small Interfering RNA.

[This corrects the article DOI: 10.3389/fbioe.2020.

Dual-Targeting Nanoparticle-Mediated Gene Therapy Strategy for Hepatocellular Carcinoma by Delivering Small Interfering RNA.

As a gene therapy strategy, RNA interference (RNAi) offers tremendous tumor therapy potential. However, its therapeutic efficacy is restricted by its inferior ability for targeted delivery and cellular uptake of small interfering RNA (siRNA). This study sought to develop a dual-ligand nanoparticle (NP) system loaded with siRNA to promote targeted delivery and therapeutic efficacy.