Publications by authors named "Yu-Yu Niu"
Mutations of () cause early-onset Parkinson's disease (PD) with selective neurodegeneration in humans. However, current knockout mouse and pig models are unable to recapitulate the typical neurodegenerative phenotypes observed in PD patients. This suggests that generating disease models in non-human primates (NHPs) that are close to humans is essential to investigate the unique function of PINK1 in primate brains.
View Article and Find Full Text PDFStem cell therapy (SCT) for Parkinson's disease (PD) has received considerable attention in recent years. Non-human primate (NHP) models of PD have played an instrumental role in the safety and efficacy of emerging PD therapies and facilitated the translation of initiatives for human patients. NHP models of PD include primates with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism, who are responsive to dopamine replacement therapies, similar to human PD patients.
View Article and Find Full Text PDFArticle Synopsis
- Chinese tree shrews are being explored as experimental models for various human disorders, such as depression and hepatitis infections.
- An annotated genome sequence for the Chinese tree shrew has been made publicly available, highlighting its genetic relevance.
- Phylogenomic analysis shows strong similarities between tree shrews and primates, indicating both shared and unique features that support their use in biomedical research.