Publications by authors named "Yu-Yu Chu"
Article Synopsis
- This study identifies PCMPS and PCMB as targeted covalent inhibitors of DEDDh exonucleases, which are significant for cancer and antiviral therapies.
- The research utilizes X-ray crystallography, binding assays, and molecular dynamics simulations to understand the binding sites and mechanisms of these compounds, particularly focusing on Cys409 and Cys461 in the Lassa fever virus NP exonuclease.
- Findings reveal that PCMPS induces allosteric inhibition, altering the RNA-binding lid's conformation, which is crucial for developing new TCIs as therapeutic agents.
