Publications by authors named "Yu-Ying Li"

The simultaneous presence of microplastics (MPs) and heavy metals in soil may result in heightened toxicity, causing more significant adverse effects on plant growth. Plant growth-promoting rhizobacteria (PGPR) have demonstrated significant capacities in alleviating the toxic stress caused by the combined pollution of heavy metals and other contaminants. However, research on the impacts and processes of PGPR in alleviating stress induced by the combined pollution from MPs and heavy metals is still insufficient.

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Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a critical method for diagnosing lung cancer. While EBUS-TBNA is commonly performed under conscious sedation, the potential benefits of conducting the procedure under general anesthesia and incorporating rapid on-site evaluation (ROSE) to enhance diagnostic yield remain uncertain. This study aims to investigate the impact of anesthesia methods and ROSE on the diagnostic efficacy of EBUS-TBNA for lung cancer.

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Ankle-foot orthoses (AFOs) have been commonly prescribed for stroke survivors with foot drop, but their impact on the contractions of paretic tibialis anterior (TA) and medial gastrocnemius (MG) has remained inconclusive. This study thus investigated the effect of AFOs on these muscle contractions in stroke survivors. The contractions of paretic TA and MG muscles were assessed in twenty stroke patients and compared between walking with and without AFOs, using a novel wearable dynamic ultrasound imaging and sensing system.

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Background: Bacillus Calmette-Guérin (BCG) is capable of enhancing the infiltration of immune cells into the tumour. However the temporal dynamics of immune cell patterns in patients receiving BCG instillation remains unclear.

Methods: Ninety-six patients who underwent intravesical BCG therapy, comprising 46 responders and 50 non-responders, were retrospectively enroled to explore the evolving immune landscape.

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  • The development of a biosensor to accurately measure luteolin levels is important due to its health benefits at specific concentrations.* ! -
  • The biosensor utilizes HRP-catalyzed luteolin reactions in electrocatalytic processes, focusing on oxidation reactions to achieve precise measurements.* ! -
  • Comparison of detection methods revealed that the Square Wave Voltammetry (SWV) method is superior, providing a broader range and lower detection limit than traditional HPLC, making it a viable replacement for detecting luteolin in Traditional Chinese Medicine.* !
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  • Luteolin possesses anti-inflammatory, antioxidant, and antitumor properties, making its detection crucial in drug development and functional foods.
  • A new method was developed using a modified glassy carbon electrode that combines horseradish peroxidase with metal-organic frameworks and carbon nanotubes to enhance selectivity and conductivity for luteolin detection.
  • The resulting biosensor demonstrated a linear detection range of 1.0 × 10 to 6.0 μM, a detection limit of 25.3 nM, and effective long-term stability, successfully detecting luteolin in various vegetables like carrots, celery, and cauliflower.
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  • The Danjiangkou Reservoir is essential for the South-to-North Water Diversion Project and hosts a diverse community of bacterioplankton, but little is known about its nitrogen and phosphorus cycles.
  • This study used metagenomics to analyze how bacterioplankton communities vary across different depths in the reservoir and identified key factors influencing their composition, such as temperature and dissolved oxygen.
  • Results showed that specific genes related to nitrogen and phosphorus cycles were more abundant in surface and bottom layers compared to the middle layer, with Proteobacteria, Actinobacteria, and Planctomycetes being dominant groups.
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Combined microplastic and heavy metal pollution (CM-HP) has become a popular research topic due to the ability of these pollutants to have complex interactions. Plant growth-promoting rhizobacteria (PGPR) are widely used to alleviate stress from heavy metal pollution in plants. However, the effects and mechanisms by which these bacteria interact under CM-HP have not been extensively studied.

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  • Neoadjuvant immune checkpoint blockade combined with chemoradiotherapy shows promising results for patients with locally advanced esophageal squamous cell carcinoma, but the impact on the tumor immune microenvironment requires further study.
  • In a study of 41 patients, tissue samples were analyzed before and after treatment to observe changes in immune cell patterns, revealing that different immune responses are linked to pathologic complete response (pCR) status.
  • Results indicated that pCR patients had fewer CD86+ cells post-treatment, while non-pCR patients showed increased CD86+ cell density, highlighting the complex interactions of immune cells during therapy.
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The green and efficient remediation of soil cadmium (Cd) is an urgent task, and plant-microbial joint remediation has become a research hotspot due to its advantages. High-throughput sequencing and metabolomics have technical advantages in analyzing the microbiological mechanism of plant growth-promoting bacteria in improving phytoremediation of soil heavy metal pollution. In this experiment, a pot trial was conducted to investigate the effects of inoculating the plant growth-promoting bacterium sp.

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Periodontal defects present a significant challenge in dentistry, necessitating innovative solutions for comprehensive regeneration. Traditional restoration methods have inherent limitations in achieving complete and functional periodontal tissue reconstruction. Tissue engineering, a multidisciplinary approach integrating cells, biomaterials, and bioactive factors, holds tremendous promise in addressing this challenge.

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  • The study investigates how microplastics (MPs) and cadmium (Cd) affect the growth of energy sorghum in agricultural soil, examining different types, sizes, and concentrations of MPs alongside Cd.
  • Results indicate that the combination of MPs and Cd influences the sorghum's dry weight and Cd accumulation, with increased stress noted as Cd levels rise.
  • High-throughput sequencing reveals that combined pollution boosts bacterial diversity and affects key nitrogen and phosphorus cycling genes in the rhizosphere, highlighting the importance of the type of MP in environmental assessments.
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  • - Amyotrophic lateral sclerosis (ALS) is marked by TDP-43 protein aggregates, and the study investigates whether detecting phosphorylated TDP-43 (pTDP-43) in muscle biopsies can help diagnose ALS more effectively.
  • - The research involved muscle biopsies from 18 ALS patients and 54 non-ALS controls, revealing that 94.4% of ALS patients had abnormal pTDP-43 aggregation compared to 29.6% of controls, indicating a strong correlation.
  • - The findings suggest that pTDP-43 accumulation is detectable in muscle tissues before clinical symptoms appear, potentially making it a valuable diagnostic biomarker for early ALS detection.
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Composite pollution by microplastics and heavy metals poses a potential threat to the soilplant system and has received increasing attention. Plant growth-promoting bacteria (PGPB) have good application potential for the remediation of combined microplastic and heavy metal pollution, but few related studies exist. The present study employed a pot experiment to investigate the effects of inoculation with the PGPB Bacillus sp.

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With the vigorous development of agriculture in China, plastic mulch film and pesticides are widely used in agricultural production. However, the accumulation of microplastics (formed by the degradation of plastic mulch film) and pesticides in soil has also caused many environmental problems. At present, the environmental biological effects of microplastics or pesticides have been reported, but there are few studies on the combined effects on crop growth and the rhizosphere soil bacterial community.

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Background: The primary objective of this investigation was to assess the impact of pyrroline-5-carboxylate reductase 1 (PYCR1) on the progression of gastric cancer (GC), specifically focusing on tumor growth and metastatic potential.

Methods: Surgical specimens from patients with different stages of GC were assayed for PYCR1 expression using immunohistochemistry. PYCR1 expression was manipulated by depletion or overexpression approaches in GC cells, and these cells were applied to explore the functional roles of PYCR1.

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Microplastics can become potential transport carriers of other environmental pollutants (such as heavy metals), so the combined pollution of microplastics and heavy metals has attracted increasing attention from researchers. To explore the mechanism of plant growth-promoting bacteria VY-1 alleviating the combined pollution stress of heavy metals and microplastics in sorghum, the effects of inoculation on biomass and accumulation of heavy metals in sorghum were analyzed using a hydroponics experiment, and the effects of inoculation on gene expression in sorghum were analyzed via transcriptomics. The results showed that the combined pollution of polyethylene (PE) and cadmium (Cd) decreased the dry weight of above-ground and underground parts by 17.

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Clear cell renal cell carcinoma (ccRCC) is of poor clinical outcomes, and currently lacks reliable prognostic biomarkers. By analyzing the datasets of the Cancer Genome Atlas (TCGA) and the Clinical Proteomic Tumor Analysis Consortium (CPTAC), we established a five-protein prognostic signature containing GBP2, HLA-DRA, ISG15, ISG20 and ITGAX. Our data indicate that this signature was closely correlated with advanced stage, higher pathological grade, and unfavorable survivals in patients with ccRCC.

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Background: Phthalates have been reported to impair fertility in various studies. However, evidence exploring the associations between phthalate metabolites in follicular fluid (FF) and reproductive outcomes is lacking.

Objectives: To investigate the associations between phthalate metabolite concentrations in FF and fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes among women recruited from a fertility clinic.

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The combined pollution of microplastics and heavy metals can potentially interact. This may have an important impact on the growth and development of plants and the rhizosphere microbial community and function. In this study, the effects of heavy metal cadmium combined with different types of microplastics(PE and PS), different particle sizes(13 μm and 550 μm), and different concentrations(0.

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  • - Seneca Valley virus (SVV) can lead to serious diseases in pregnant sows and high mortality rates in newborn piglets, causing economic losses in pig farming.
  • - The 3C protease is essential for SVV's development, affecting both the virus's replication process and the host's immune response by targeting key factors that regulate these processes.
  • - Recent studies focus on the 3C protease's roles in boosting viral replication, influencing cell death, and bypassing host immunity, which could guide future strategies for preventing SVV infections.
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Microplastics (MPs) can act as carriers for environmental pollutants; therefore, MPs combined with heavy metal pollution are attracting increasing attention from researchers. In this study, the potential of the plant growth-promoting bacterium Bacillus sp. SL-413 to mitigate the stress caused by exposure to both MPs and cadmium (Cd) in sorghum plants was investigated.

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Constructing a sensitive and efficient sensor for determination of metronidazole (MNZ) is crucial in food field. Herein, a new cyclotriveratrylene-based metal-organic framework (MOF), namely, [CdL(cyclen)(HO)] (1), was constructed by self-assembly of functionalized 5,6,12,13,19,20-hexacarboxy-propoxy-cyclotriveratrylene (HL), 1,4,7,10-tetraazacyclododecane (cyclen) and Cd(II) cation under solvothermal condition. In 1, adjacent Cd(II) cations are linked by L to produce a 2D polymeric structure with carboxylate and phenolic oxygen atoms.

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Swine acute diarrhoea syndrome coronavirus (SADS-CoV), which is a recently discovered enteric coronavirus, is the major aetiological agent that causes severe clinical diarrhoea and intestinal pathological damage in pigs, and it has caused significant economic losses to the swine industry. Nonstructural protein 5, also called 3C-like protease, cleaves viral polypeptides and host immune-related molecules to facilitate viral replication and immune evasion. Here, we demonstrated that SADS-CoV nsp5 significantly inhibits the Sendai virus (SEV)-induced production of IFN-β and inflammatory cytokines.

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The leaching risk of heavy metals in soil has a large spatial variability on a regional scale. Taking the Chang-Zhu-Tan area as the research object, this work studied the distribution and influencing factors of available contents and solid-solution partition coefficient () of Cd and Pb in soil with land uses and clarified the environmental risk of heavy metals in soil based on values measured by CaCl (soil-to-water ratio, 1:0.5).

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