Publications by authors named "Yu-Yang Meng"
Colorectal cancer (CRC), a major global health concern, may be influenced by dietary protein digestibility impacting gut microbiota and metabolites, which is crucial for cancer therapy effectiveness. This study explored the effects of a casein protein diet (CTL) versus a free amino acid (FAA)-based diet on CRC progression, gut microbiota, and metabolites using carcinogen-induced (AOM/DSS) and spontaneous genetically induced ( mice) CRC mouse models. Comprehensive approaches including 16s rRNA gene sequencing, transcriptomics, metabolomics, and immunohistochemistry were utilized.
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- Renal cell carcinoma (RCC), particularly clear cell RCC (ccRCC), was the focus of a study analyzing single-cell RNA sequencing (scRNA-seq) data to understand how the tumor microenvironment (TME) connects with clinical outcomes and immunotherapy responses.
- Researchers identified three distinct differentiation subsets of ccRCC cells and categorized ccRCC samples into four molecular subtypes based on differentiation-related genes (DRGs), which correlated with patient prognosis and immune checkpoint gene expression.
- The study developed a prognostic risk signature (PRS) and an easy-to-use nomogram based on the PRS, enabling more accurate predictions of ccRCC patient outcomes and emphasizing the importance of TME evolution in treatment responses.
Background: The long noncoding RNA (lncRNA) OTUD6B antisense RNA 1 (OTUD6B-AS1) is oriented in an antisense direction to the protein-coding gene OTUD6B on the opposite DNA strand. TCGA database data show that the expression of the lncRNA OTUD6B-AS1 is downregulated and that OTUD6B-AS1 acts as an antioncogene in a variety of tumors. However, the expression and biological functions of the lncRNA OTUD6B-AS1 are still unknown in tumors, including clear cell renal cell carcinoma (ccRCC).
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