Injectable hydrogel platform with biodegradable Dawson-type polyoxometalate and R848 for combinational photothermal-immunotherapy of cancer.

Photothermal therapy (PTT) is a powerful strategy for cancer treatment with minimal invasiveness but still limited by lack of long-term efficacy against tumor recurrence and toxicity concerns about the slow biodegradability of the PTT agents. Herein, an injectable hydrogel platform (R848/POM@GG) of gellan gum co-loaded with Dawson-type {PMo} polyoxometalate (POM) and Toll-like receptors agonist resiquimod (R848) is developed for combinational photothermal-immunotherapy of cancer. The POM-based gellan gum hydrogel (POM@GG) exhibits high photothermal conversion efficiency (63.

Microwave-Assisted Synthesis of Tris-Anderson Polyoxometalates for Facile CO Cycloaddition.

Four new tris-Anderson polyoxometalates (POMs), (NH)[ZnMoO(CHNO)(OH)]·4HO (), (NH)[CuMoO(CHNO)(OH)]·4HO (), (TBA)(NH)[ZnMoO(CHO)(OH)]·10HO () (TBA = -CHN), and (NH)[CuMoO(CHO)]·16HO (), were synthesized by a microwave-assisted method. Single-crystal X-ray diffraction revealed that and contained a tris (trihydroxyl organic compounds) ligand grafted on one side, while two tris ligands were grafted on two sides to form χ/δ and δ/δ isomers in and , respectively. H and C NMR spectra of the χ/δ isomer were obtained for the first time, with six methylenes showing six peaks in the H NMR spectrum and only four peaks in the C NMR spectrum.

Hippocampal vascularization: Proposal for a new classification.

Background: Anatomy of the hippocampal arterial supply is key to successful surgeries in this area. The goal of the current study is to present the results we obtained from our microsurgical dissections of the temporal lobe and to propose a new classification for the hippocampal arteries (HAs).

Methods: Fifty-six brain hemispheres were analyzed.

Microsurgical anatomy of language.

The localizationist model, which focused on classical cortical areas such as Broca's and Wernicke's, can no longer explain how language processing works. Over recent years, several studies have revealed new language-related cortical and subcortical areas, resulting in a transition from localizationist concepts to a hodotopical model. These studies have described language processing as an extensive and complex network of multiple interconnected cortical areas and subcortical pathways, differing from the classical circuit described by the localizationist perspective.