Publications by authors named "Yu-Xue Jiao"
Article Synopsis
- Mutations in mitochondrial tRNA genes are linked to type 2 diabetes mellitus (T2DM), with a focus on novel variants found in a Chinese family.
- A study aimed to evaluate the genetic and biochemical impacts of these variants using specially created cell lines, comparing them to healthy controls.
- Results showed that one variant led to significant mitochondrial dysfunction and increased oxidative stress, while the other did not appear to affect mitochondrial function significantly.
pH-sensitive fluorescent proteins have revolutionized the field of cellular imaging and physiology, offering insight into the dynamic pH changes that underlie fundamental cellular processes. This comprehensive review explores the diverse applications and recent advances in the use of pH-sensitive fluorescent proteins. These remarkable tools enable researchers to visualize and monitor pH variations within subcellular compartments, especially mitochondria, shedding light on organelle-specific pH regulation.
View Article and Find Full Text PDFThe roles of mitochondrial tRNA mutations in non-dystrophic myotonias.
Mitochondrial DNA B Resour
November 2020
According a recent report by Heidari et al., a mutational screening for candidate pathogenic mitochondrial tRNA (mt-tRNA) mutations were performed in 45 Iranian patients with non-dystrophic myotonia (NDM) and 70 control subjects. Through PCR amplification and direct sequence analysis, nine mt-tRNA mutations were identified: tRNA T4454C, tRNA A5568G, tRNA T5794C, tRNA A10438T and T10462C, tRNA A12308G, tRNA A15907G, A15924G and G15928A.
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