Publications by authors named "Yu-Xuan Gan"
Ethnopharmacological Relevance: Huangqin Decoction (HQD), a traditional Chinese medicinal (TCM) formula chronicled in Shang Han Lun, has been used to treat gastrointestinal diseases for nearly 1800 years.
Objective: To investigate the effects and underlying mechanisms of HQD on ulcerative colitis (UC).
Methods: The bioactive compounds in HQD were obtained from the traditional Chinese medicine systems pharmacology database.
Article Synopsis
- Huangqin decoction (HQD) has been traditionally used to treat gastrointestinal diseases, and this study explored its anti-inflammatory effects on ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in mice.
- HQD treatment significantly reduced weight loss, improved disease symptoms, restored colon length, and decreased inflammatory mediators by inhibiting specific signaling pathways (Ras-PI3K-Akt-HIF-1α and NF-κB).
- Additionally, HQD improved gut microbiota diversity, indicating its potential as a treatment for UC.
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Nevertheless, no first-line therapy exists. Hepatic steatosis is the earliest stage of NAFLD, which is characterized by an accumulation of hepatic lipids.
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