Modulating the Morphology of Gold Graphitic Nanocapsules for Plasmon Resonance-Enhanced Multimodal Imaging.

With their unique optical properties and distinct Raman signatures, graphitic nanomaterials can serve as substrates for surface-enhanced Raman spectroscopy (SERS) or provide signal amplification for bioanalysis and detection. However, a relatively weak Raman signal has limited further biomedical applications. This has been addressed by encapsulating gold nanorods (AuNRs) in a thin graphitic shell to form gold graphitic nanocapsules.

Simultaneous tracking of drug molecules and carriers using aptamer-functionalized fluorescent superstable gold nanorod-carbon nanocapsules during thermo-chemotherapy.

Controlling and monitoring the drug delivery process is critical to its intended therapeutic function. Many nanocarrier systems for drug delivery have been successfully developed. However, biocompatibility, stability, and simultaneously tracing drugs and nanocarriers present significant limitations.

Alkyne-functionalized superstable graphitic silver nanoparticles for Raman imaging.

Noble metals, especially gold, have been widely used in plasmon resonance applications. Although silver has a larger optical cross section and lower cost than gold, it has attracted much less attention because of its easy corrosion, thereby degrading plasmonic signals and limiting its applications. To circumvent this problem, we report the facile synthesis of superstable AgCu@graphene (ACG) nanoparticles (NPs).

[Emergence of 16S rRNA methylase gene rmtB in Klebsiella pneumoniae isolates from the inpatients in Zhejiang Province, China].

Objective: To investigate the presence and genetic background of 16S rRNA methylase gene and Aminoglycoside modifying enzymes (AMEs) genes in Klebsiella pneumoniae isolated from the People's Liberation Army 98th Hospital, Huzhou district, Zhejiang province, China.

Methods: 25 strains of Klebsiella pneumoniae were isolated from the inpatients between September, 2005 and April, 2006. 6 kinds of 16S rRNA methylase gene (including armA, rmtA, rmtB, rmtC, rmtD and npmA), 6 kinds of AMEs genes [including aac (3)-I, aac (3)-II, aac (6')-I, aac (6')-II, ant (3")-I and ant (2")-I], intI1, intI2, intI3, mercuric reductase gene merA (merA gene were the collective genetic markers of transposons of Tn21 and Tn501) and tnpA (tnpA gene were the collective genetic markers of transposons of Tn1, Tn2,Tn3 and Tn1000) were analyzed by PCR and verificated by DNA sequencing.