MIF/CD74 axis in hepatic stellate cells mediates HBV-related liver fibrosis.

Chronic hepatitis B virus (HBV) infection is a major risk factor for liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Despite advances in understanding HBV-related liver diseases, effective therapeutic strategies remain limited. Macrophage migration inhibitory factor (MIF) has been implicated in various inflammatory and fibrotic conditions, but its role in HBV-induced liver fibrosis has not been fully explored.

Hepatitis B virus-induced cirrhosis: Mechanisms, global variations, and treatment advances.

We focus on hepatitis B virus (HBV)-induced cirrhosis, global differences, and the evolution of antiviral treatment strategies. Chronic HBV (CHB) infection affects more than 250 million people globally, leading to cirrhosis and hepatocellular carcinoma. The aim of this article was to synthesize the current understanding of the pathophysiological mechanisms and clinical consequences of HBV-induced cirrhosis, and explore differences in disease progression between geographic regions.

Boron Clusters Escort Doxorubicin Squashing Into Exosomes and Overcome Drug Resistance.

Exosome-based drug delivery holds significant promise for cancer chemotherapy. However, current methods for loading drugs into exosomes are inefficient and cost-prohibitive for practical application. In this study, boron clusters are mixed with doxorubicin (DOX) and exosomes, enabling the efficient encapsulation of DOX into exosomes through a superchaotropic effect.

Evidence for early encoding of speech in blind people.

Blind listeners rely more on their auditory skills than the sighted to adapt to unavailable visual information. However, it is still unclear whether the blind has stronger noise-related modulation compared with the sighted when speech is presented under adverse listening conditions. This study aims to address this research gap by constructing noisy conditions and syllable contrasts to obtain auditory middle-latency response (MLR) and long-latency response (LLR) in blind and sighted adults.

[Effects of Mercury Pollution on Soil Organic Carbon Stability and Carbon-fixing Microbial Communities].

To elucidate the effects of Hg pollution on soil organic carbon stability and autotrophic microbial carbon assimilation, the characteristics of soil CO emission rate, organic carbon components, and and functional microorganisms before and after 29 d of Hg pollution were studied using indoor culture experiments and molecular biology techniques. The results showed that the effects of different levels of Hg pollution on soil CO emission rates were different. High levels of Hg （S2,S3,and S5） inhibited soil CO cumulative emissions, whereas low levels of Hg （S1,S4,and S6） promoted soil carbon emissions.

Constructing Diverse Inlier Consistency for Partial Point Cloud Registration.

Partial point cloud registration aims to align partial scans into a shared coordinate system. While learning-based partial point cloud registration methods have achieved remarkable progress, they often fail to take full advantage of the relative positional relationships both within (intra-) and between (inter-) point clouds. This oversight hampers their ability to accurately identify overlapping regions and search for reliable correspondences.

Screening and Predictive Biomarkers for Down Syndrome Through Amniotic Fluid Metabolomics.

Background: Down syndrome (DS) is a congenital disorder caused by the presence of an extra copy of all or part of chromosome 21. It is characterized by significant intellectual disability, distinct facial features, and growth and developmental challenges. The utilization of metabolomics to analyze specific metabolic markers in maternal amniotic fluid may provide innovative tools and screening methods for investigating the early pathophysiology of trisomy 21 at the functional level.

Pathogenesis and research progress of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.

In this editorial, we comment on the article by Mei . Nonalcoholic steatohepatitis (NASH) is a severe inflammatory subtype of nonalcoholic fatty liver disease (NAFLD) with pathological features including steatosis, hepatocellular damage, and varying degrees of fibrosis. With the epidemic of metabolic diseases and obesity, the prevalence of NAFLD in China has increased, and it is now similar to that in developed countries; thus, NAFLD has become a major chronic liver disease in China.

Baicalein ameliorates chronic itch in ACD mice by suppressing the spinal astrocytic STAT3-LCN2 cascade.

Chronic itch is a maladaptive and debilitating symptom in patients with allergic contact dermatitis (ACD), adversely affecting their quality of life. There is a lack of effective treatments for ACD-associated uncontrollable itch. In this study, we explored the antipruritic effects of baicalein (BE), a bioactive flavonoid extracted from the root of Scutellaria baicalensis Georgi, and the underlying mechanisms in alleviating chronic itch triggered by diphenylcyclopropenone (DCP) in a mouse model of ACD.

Scopolamine for patients with motion sickness: a systematic review and meta-analysis with trial sequential analysis.

Background: Scopolamine has been demonstrated to relieve motion sickness. However, repeated significance testing may increase false-positive results.

Objectives: Review the efficacy and safety of scopolamine in the prevention of motion sickness by performing a meta-analysis with Trial Sequential Analysis (TSA).

Hinokiflavone exerts dual regulation on apoptosis and pyroptosis via the SIX4/Stat3/Akt pathway to alleviate APAP-induced liver injury.

Hinokiflavone (HF), classified as a flavonoid, is a main bioactive compound in Platycladus orientalis and Selaginella. HF exhibits activities including anti-HIV, anti-inflammatory, antiviral, antioxidant and anti-tumor effects. The study aimed to explore the function and the mechanisms of HF on acetaminophen (APAP)-induced acute liver injury.

A luminescent CuIPS-type binuclear complex and its fluorescence sensing for pyridine.

Luminescent Cu complexes are an important class of coordination compounds due to their relative abundance, low cost and ability to display excellent luminescence. The title CuIPS-type binuclear complex, di-μ-iodido-bis[(thiourea-κS)(triphenylphosphine-κP)copper(I)], [CuI(CHNS)(CHP)], conventionally abbreviated as CuITPPTU, where TPP and TU represent triphenylphosphine and thiourea, respectively, is described. In this complex, each Cu atom adopts a CuIPS four-coordination mode and pairs of atoms are connected to each other by two μ-I ligands to form a centrosymmetric binuclear cluster.

Unveiling the Younger Face of Gastric Cancer: A Comprehensive Review of Epidemiology, Risk Factors, and Prevention Strategies.

Gastric cancer poses a significant global health challenge, with high incidence and mortality rates each year. Despite advancements in screening and treatment, late detection remains a critical issue. Efforts to address this include raising public awareness and implementing targeted screening programs for high-risk populations.

Minocycline in the eradication of infection: A systematic review and meta-analysis.

Background: Difficulty in obtaining tetracycline, increased adverse reactions, and relatively complicated medication methods have limited the clinical application of the classic bismuth quadruple therapy. Therefore, the search for new alternative drugs has become one of the research hotspots. In recent years, minocycline, as a semisynthetic tetracycline, has demonstrated good potential for eradicating () infection, but the systematic evaluation of its role remains lacking.

Synthesis of Heterocyclic Ring-Fused Bisnoralcohol Derivatives as Novel Small-Molecule Antiosteoporosis Agents.

A series of heterocyclic ring-fused derivatives of bisnoralcohol (BA) were synthesized and evaluated for their inhibitory effects on RANKL-induced osteoclastogenesis. Most of these derivatives possessed potent antiosteoporosis activities in a dose-dependent manner. Among these compounds, (SH442, IC = 0.

GnRH-driven FTO-mediated RNA mA modification promotes gonadotropin synthesis and secretion.

Background: Gonadotropin precisely controls mammalian reproductive activities. Systematic analysis of the mechanisms by which epigenetic modifications regulate the synthesis and secretion of gonadotropin can be useful for more precise regulation of the animal reproductive process. Previous studies have identified many differential mA modifications in the GnRH-treated adenohypophysis.

Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer's disease.

Background: Adult neurogenesis occurs in the subventricular zone (SVZ) and the subgranular zone of the dentate gyrus in the hippocampus. The neuronal stem cells in these two neurogenic niches respond differently to various physiological and pathological stimuli. Recently, we have found that the decrement of carboxypeptidase E (CPE) with aging impairs the maturation of brain-derived neurotrophic factor (BDNF) and neurogenesis in the SVZ.

Common Pathophysiological Mechanisms and Treatment of Diabetic Gastroparesis.

Diabetic gastroparesis (DGP) is a common complication of diabetes mellitus, marked by gastrointestinal motility disorder, a delayed gastric emptying present in the absence of mechanical obstruction. Clinical manifestations include postprandial fullness and epigastric discomfort, bloating, nausea, and vomiting. DGP may significantly affect the quality of life and productivity of patients.

Diatomite@MoS Nanocomposite Layers as Composite Coating Targeting for Mg Alloys Endowed with Properties of Anticorrosion and Antiwear.

Molybdenum disulfide (MoS) demonstrates promising applications in enhancing the corrosion and wear resistance of metals, but the susceptibility of this nanomaterial to agglomeration hinders its overall performance. In this study, the externally assisted corrosion inhibitor sodium molybdate (SM) was successfully constructed in diatomaceous earth (DE) and molybdenum disulfide (MoS). This not only served as a molybdenum source for MoS but also enabled the preparation of DE@MoS-SM microcapsules, achieving a corrosion inhibitor loading of up to 23.

Thriving at work as a mediator of the relationship between psychological resilience and the work performance of clinical nurses.

Objective: This study aims to investigate the relationship between psychological resilience, thriving at work, and work performance among nurses, as well as analyse the mediating role of thriving at work in the relationship between psychological resilience and the work performance of nurses. The findings are intended to serve as a reference for nursing managers to design tailored work performance intervention programs.

Method: Using convenience sampling, 308 clinical nurses were selected from a tertiary hospital in Changsha City, Hunan Province, China, from February to April 2023.

Two novel pathogenic variants in the TCOF1 found in two Chinese cases of Treacher Collins syndrome.

Background: Treacher Collins Ι syndrome (TCS1, OMIM:154500) is an autosomal dominant disease with a series of clinical manifestations such as craniofacial dysplasia including eye and ear abnormalities, small jaw deformity, cleft lip, as well as repeated respiratory tract infection and conductive hearing loss. Two cases of Treacher Collins syndrome with TCOF1(OMIM:606847) gene variations were reported in the article, with clinical characteristics, gene variants and the etiology.

Methods: The clinical data of two patients with Treacher Collins syndrome caused by TCOF1 gene variation were retrospectively analyzed.

Effect of early serum phosphate disorder on in-hospital and 28-day mortality in sepsis patients: a retrospective study based on MIMIC-IV database.

Background: This study aims to assess the influence of early serum phosphate fluctuation on the short-term prognosis of sepsis patients.

Methods: This retrospective study used the Medical Information Mart for Intensive Care IV database to analyze serum phosphate levels in sepsis patients within 3 days of ICU admission. According to the absolute value of delta serum phosphate (the maximum value minus the minimum value of serum phosphorus measured within three days), the patients were divided into four groups, 0-1.

Effectiveness of immune checkpoint inhibitors in combination with tyrosine kinase inhibitors in patients with advanced or metastatic colorectal carcinoma with either mismatch repair proficient or metastatic microsatellite stable disease: A systematic review and meta‑analysis.

Immune checkpoint inhibitors (ICIs) have limited efficacy in mismatch repair proficient (pMMR) or metastatic microsatellite stable (MSS) advanced or metastatic colorectal cancer (mCRC). ICIs, in conjunction with tyrosine kinase inhibitors (TKIs) possessing anti-angiogenic properties, serve as a potential strategy for circumventing the resistance exhibited by MSS or pMMR mCRC to immunotherapeutic interventions. The present study aimed to evaluate efficacy and safety of ICIs + TKIs and provide a reference for the treatment of CRC.

EGF-driven EGFR/miR-27b-3p/FOXO1 promotes rat FSH synthesis and secretion.

The adenopituitary secretes follicle-stimulating hormone (FSH), which plays a crucial role in regulating the growth, development, and reproductive functions of organisms. Investigating the process of FSH synthesis and secretion can offer valuable insights into potential areas of focus for reproductive research. Epidermal growth factor (EGF) is a significant paracrine/autocrine factor within the body, and studies have demonstrated its ability to stimulate FSH secretion in animals.