Publications by authors named "Yu-Xin Xian"
Background: Prostate cancer is known to have ethnic and regional differences. The study aimed to clinically evaluate the detection rate of prostate cancer on transrectal ultrasonography (TRUS)-guided prostate biopsy and analyze its characteristics among the northern Han Chinese population at a single center.
Methods: Between October 2009 and September 2016, a total of 1027 Chinese men, who had undergone TRUS-guided prostate biopsy at Qingdao Municipal Hospital, were retrospectively analyzed.
Article Synopsis
- This study aimed to compare the effectiveness of continuous subcutaneous insulin aspart infusion (CSII) versus multiple daily injections (MDI) using long-acting insulin analogues (glargine or detemir) for poorly controlled type 2 diabetes patients.
- 119 patients were randomly divided into three groups: CSII (Group A), glargine-based MDI (Group B), and detemir-based MDI (Group C).
- Results showed that Group A achieved better blood glucose control in a shorter time with lower insulin doses compared to Groups B and C, with no significant differences between the glargine and detemir groups.
Aim: To evaluate the correlation between nonalcoholic fatty liver disease (NAFLD) and microvascular complications in type 2 diabetes mellitus (T2DM).
Methods: Data were obtained from 1217 inpatients with T2DM (757 females, 460 males; aged 63.39 ± 12.
Metformin appears to be involved in altering energy expenditure and thermogenesis, and could affect hypothalamic feeding circuits. However, it is not clear whether metformin is able to cross the blood-brain barrier (BBB) to reach the hypothalamus and exert a direct effect on the central nervous system. Here we show the presence of metformin in cerebrospinal fluid (CSF) of diabetic rats administered orally with metformin which was confirmed by detecting the concentration of metformin with liquid chromatography-tandem mass spectrometry.
View Article and Find Full Text PDFBackground: The delivery of glucose from the blood to the brain involves its passage across the endothelial cells of the blood-brain barrier (BBB), which is mediated by the facilitative glucose transporter protein 1 (GLUT(1)), and then across the neural cell membranes, which is mediated by GLUT(3). This study aimed to evaluate the dynamic influence of hyperglycemia on the expression of these GLUTs by measuring their expression in the brain at different blood glucose levels in a rat model of diabetes. This might help to determine the proper blood glucose threshold level in the treatment of diabetic apoplexy.
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