Inhibition of visfatin alleviates sepsis-induced intestinal damage by inhibiting Hippo signaling pathway.

Background: The aim of this study is to investigate role of Visfatin, one of the pro-inflammatory adipokines, in sepsis-induced intestinal injury and to clarify the potential mechanism.

Methods: C57BL/6 mice underwent cecal ligation and puncture (CLP) surgery to establish sepsis model in vivo. Intestinal epithelial cells were stimulated with LPS to mimic sepsis-induced intestinal injury in vitro.

Ulinastatin for acute lung injury and acute respiratory distress syndrome: A systematic review and meta-analysis.

Aim: To investigate the efficacy and safety of ulinastatin for patients with acute lung injury (ALI) and those with acute respiratory distress syndrome (ARDS).

Methods: A systematic review of randomized controlled trials (RCTs) of ulinastatin for ALI/ARDS was conducted. Oxygenation index, mortality rate [intensive care unit (ICU) mortality rate, 28-d mortality rate] and length of ICU stay were compared between ulinastatin group and conventional therapy group.

[Analysis of the risk factors for early death in acute severe traumatic cervical spinal cord injury].

Objective: To survey the risk factors for early death of patients with acute severe traumatic cervical spinal cord injury.

Methods: A retrospective analysis of data of consecutive patients with acute severe traumatic cervical spinal cord injury admitted from January 1st 1994 to October 1st 2012 were made. The patients died within 30 days or not were allocated for death group or survival group.

[The effect of neuromuscular blocking agents on prognosis of patients with acute respiratory distress syndrome: a meta analysis].

Objective: To determine the effects of neuromuscular blocking agent (NMBA) on prognosis of patients with acute respiratory distress syndrome (ARDS).

Methods: PubMed database, the Cochrane Library, EMBASE, Excepta Media, CBM, CNKI and other sources were used for retrieving the pertinent literature. All randomized controlled trials (RCTs) on NMBA treating ARDS patients were enrolled.

[Effect of 45 degree angle semirecumbent position on ventilator-associated pneumonia in mechanical ventilated patients: a meta-analysis].

Objective: To systemically analyze the effect of 45 degree angle semirecumbent position on the incidence of ventilator-associated pneumonia (VAP) and other outcomes in mechanical ventilated patients, and to evaluate whether 45 degree angle semirecumbent position is superior to 25 degree angle-30 degree angle head of bed (HOB).

Methods: The randomized controlled trials (RCTs) comparing the effect of different HOB on the outcomes of mechanical ventilated patients were searched (from 1st January 1990 to 20th July 2012) from five databases including the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, China Knowledge Resource Integrated Database (CNKI), and Wanfang Database. Meta analysis was conducted using RevMan 5.

Vesicular glutamate transporter-3 contributes to visceral hyperalgesia induced by Trichinella spiralis infection in rats.

Background: According to a recent study, vesicular glutamate transporter-3 (VGLUT3) contributes to injury-induced mechanical hyperalgesia in mice.

Aims: The aims of the study were to investigate whether VGLUT3 is involved in visceral pain, and whether transient intestinal infection or acute cold restraint stress (ACRS) affects VGLUT3 expression levels in rats.

Methods: Changes in VGLUT3 and c-Fos proteins were evaluated in rats which received noxious colorectal distension (CRD) stimulation.

[Combined effects of elevated body position on gastroesophageal reflux and intra-abdominal pressure in mechanical ventilated patients].

Objective: To investigate the combined effects of elevated body position on gastroesophageal reflux and intra-abdominal pressure (IAP) in patients undergoing mechanical ventilation (MV) who were receiving enteral nutrition, and to find out their proper height of head of bed.

Methods: The continuous pH-impedance and bladder pressure (reflecting IAP) at different body positions (0 degree angle, 20 degree angle, 30 degree angle, 45 degree angle) in 6 hours were monitored in 41 MV and enteral nutrition supported patients. The patients who did not have previous gastroesophageal reflux disease (GERD) were admitted to intensive care unit (ICU) of Peking University Third Hospital from March 2010 to December 2010 were included in the study.

[Establishment of irritable bowel syndrome rat model by combination of intestinal infection with Trichinella spiralis and acute stress].

Objective: To establish the irritable bowel syndrome (IBS) rat model by the combination of acute stress and transient intestinal infection with Trichinella spiralis (T.S.).

Alteration of cholinergic and peptidergic neurotransmitters in rat ileum induced by acute stress following transient intestinal infection is mast cell dependent.

Background: Mast cells are implicated in the development of irritable bowel syndrome (IBS), which is associated with the activation of the "neural-immune" system. The aim of this study was to investigate the role of mast cells in the remodeling of cholinergic and peptidergic neurotransmitters induced by acute cold restriction stress (ACRS) post infection (PI) using mast cell deficient rats (Ws/Ws) and their wild-type controls (+/+).

Methods: Transient intestinal infection was initiated by giving 1500 Trichinella spiralis (T.

Multiterawatt laser system based on optical parametric chirped pulse amplification.

A compact multiterawatt laser system based on optical parametric chirped pulse amplification is demonstrated. Chirped pulses are amplified from 20 pJ to 900 mJ by two lithium triborate optical parametric preamplifiers and a final KDP optical parametric power amplifier with a pump energy of 5 J at 532 nm from Nd:YAG-Nd:glass hybrid amplifiers. After compression, we obtained a final output of 570-mJ-155-fs pulses with a peak power of 3.