Publications by authors named "Yu-Xin Hua"
Wnt5a plays an important role in cell development and maturation and is closely associated with various diseases, such as malignant tumours, metabolic disorders, fibrosis, growth and development. Recent studies have shown that Wnt5a expression and signal transduction are strongly involved in the inflammatory response. This study comprehensively reviewed the latest research progress on the association between Wnt5a and several inflammatory diseases, such as sepsis, asthma, chronic obstructive pulmonary disease, tuberculosis, rheumatoid arthritis, atherosclerosis and psoriasis vulgare.
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- Cullin-RING ubiquitin ligase 4 (CRL4) is linked to ovarian cancer development, with the protein DCAF13 playing a crucial role in this process.
- High levels of DCAF13 are associated with poor survival rates in ovarian cancer patients, and knocking it out significantly reduces cancer cell growth and movement.
- The study reveals that DCAF13 promotes tumor growth by targeting FRAS1 for degradation, which in turn activates the FAK signaling pathway, suggesting potential therapeutic targets for ovarian cancer treatment.
Article Synopsis
- Cell senescence can inhibit oncogene activation, presenting a possible strategy to disrupt tumor cell functions, particularly in ovarian cancer where S1PR1 has been found to play a significant role.* -
- In ovarian cancer, deleting S1PR1 slows cell growth and movement, promotes senescence, and enhances sensitivity to chemotherapy, particularly cisplatin.* -
- The study identifies the S1PR1-PDK1-LATS1/2-YAP signaling pathway as a key regulator of ovarian cancer cell senescence, suggesting that targeting this pathway could improve standard treatment outcomes.*
Bystander activation of T cells is defined as induction of effector responses by innate cytokines in the absence of cognate antigens and independent of T cell receptor (TCR) signaling. Here we show that C-reactive protein (CRP), a soluble pattern-recognition receptor assembled noncovalently by five identical subunits, can instead trigger bystander activation of CD4 + T cells by evoking allosteric activation and spontaneous signaling of TCR in the absence of cognate antigens. The actions of CRP depend on pattern ligand-binding induced conformational changes that result in the generation of monomeric CRP (mCRP).
View Article and Find Full Text PDFWe propose a synthesis method to design a 90° bent fair circular waveguide TE01 mode transition based on the non-uniform rational B-spline technique. The transition by this method has advantages of small geometry, high transmission with wide band and high profile fairness. An example of design of such a transition is presented.
View Article and Find Full Text PDFObjective: To study the inhibitive effect of extracts from Scindapsus aureus on alpha-glucosidase and its antioxidant activity.
Methods: The 70% ethanol extracts was extracted by petroleum, ethyl acetate and n-butanol, and the inhibitory activity against alpha-glucosidases and antioxidative effects of each fraction were determined in vitro, and the inhibitory kinetics of ethyl acetate fraction was investigated.
Results: The inhibitory activity of ethly acetate fraction against alpha-glucosidase was higher as its IC50 was 43.
Objective: To study the inhibition of extracts from Synotis erythropappa on tyrosinase.
Methods: The 70% ethanol extracts were extracted by petroleum benzine, ethyl acetate and n-butanol, and the inhibitory activities against tyrosinase of every fraction were determined in vitro and the inhibitory kinetics of ethyl acetate and n-butanol fractions were investigated.
Results: The four fractions extracted all had inhibitory activities on tyrosinase, inhibitory activities of ethyl acetate and n-butanol fraction were higher.