Identification of target genes co-regulated by four key histone modifications of five key regions in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a cancer with high morbidity and mortality. Studies have shown that histone modification plays an important regulatory role in the occurrence and development of HCC. However, the specific regulatory effects of histone modifications on gene expression in HCC are still unclear.

Discovered Key CpG Sites by Analyzing DNA Methylation and Gene Expression in Breast Cancer Samples.

Breast cancer is the most common cancer in the world, and DNA methylation plays a key role in the occurrence and development of breast cancer. However, the effect of DNA methylation in different gene functional regions on gene expression and the effect of gene expression on breast cancer is not completely clear. In our study, we computed and analyzed DNA methylation, gene expression, and clinical data in the TCGA database.

Discovering the key genes and important DNA methylation regions in breast cancer.

Background: Breast cancer is the malignant tumor with the highest incidence in women. DNA methylation has an important effect on breast cancer, but the effect of abnormal DNA methylation on gene expression in breast cancer is still unclear. Therefore, it is very important to find therapeutic targets related to DNA methylation.

The effect of key DNA methylation in different regions on gene expression in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a common cancer with high morbidity and mortality. As we all know, the alteration of DNA methylation has a crucial impact on the occurrence of HCC. However, the mechanism of the effect of DNA methylation in different regions on gene expression is still unclear.

Identification of key genes and important histone modifications in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death in the world. It has been reported that HCC is closely related to the changes of histone modifications. However, finding histone modification patterns in key genes which related to HCC is still an important task.

[Textual research on the original edition of Chongguang buzhu huangdineijing suwen (Revisions and Extensive Notes on the Plain Question of Huangdi's Inner Classic)].

It is generally held that the original edition for the revision of Su wen (Plain Questions) by the Bureau for Revising Medical Books of Northern Song dynasty was Huangdineijing suwen (Plain Questions of the Huangdi's Inner Classic) commented by WANG Bing. However, some doubtful points were found in Chongguang buzhu huangdineijing suwen (Revised and Extensive Notes on the Plain Question of Huangdi's Inner Classic) that the government of the Song dynasty had twice arranged to collate Su Wen after WANG Bing and before LIN Yi; there were also private editors. Through in-depth study of the comments of LIN Yi, it can be concluded that the new revision did not adopt the original edition of the secondary annotated edition, but that of the alternative edition of the secondary annotated edition with commentaries, which ought to be the re-collated edition on the basis of the collation of Tiansheng in the fourth year (1026) by DING Du of Jingyou in the second year (1035).

Low temperature induced synthesis of TiN nanocrystals.

TiN nanocrystals were successfully prepared through the direct reaction between TiCl(4) and NaNH(2) induced at 300 degrees C. The yield based on Ti is approximately 80%. X-ray powder diffraction indicated that the product was cubic TiN with a lattice constant of a = 4.