Shaoyao decoction restores the mucus layer in mice with DSS-induced colitis by regulating Notch signaling pathway.

Ethnopharmacological Relevance: Restoring the mucus layer is a potential strategy for treating ulcerative colitis (UC). Previous studies reported that a Chinese medicine formula Shaoyao Decoction (SYD) effectively improved UC. However, the role and mechanism of SYD in restoring the mucus layer are still vague.

Aloin A prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing the Notch signaling pathway.

Background: Previous studies reported that Aloe vera ameliorated DSS-induced colitis and promoted mucus secretion. However, the effect of Aloin A (AA), a major compound of Aloe vera, on colitis and its exact mechanism remains uncovered.

Methods: C57BL/6 mice were successively subjected to 3% DSS solution for 5 days and distilled water for 2 days.

[Relation between angiogenesis, fibrinolysis and invasion/metastasis in breast cancer].

Objective: To investigate the relation between angiogensis, fibrinolysis and invasion/metastasis in breast cancer.

Methods: The expression of urokinase-type plasminogen activator (uPA) and microvascular density (MVD) was immunohistochemically studied in 110 patients with primary breast cancer.

Results: High uPA expression was found in 59 patients (53.