Publications by authors named "Yu-Wen Diao"
RNA editing of drives early tumor invasion and metastasis in familial esophageal cancer.
Proc Natl Acad Sci U S A
June 2017
Article Synopsis
- Familial esophageal squamous cell carcinoma (ESCC) tends to have an earlier onset and a worse prognosis compared to sporadic cases, but its genetic causes are largely unknown.
- A specific gene is found to be significantly down-regulated in non-tumor tissues from familial ESCC patients, where A-to-I RNA editing of this gene correlates with lymph node metastasis.
- The study reveals that this gene acts as a metastasis suppressor, and its deregulation increases cell invasiveness and promotes cancer progression in familial ESCC cases.
Aim: To investigate the effects of our tumor vaccines on reversing immune tolerance and generating therapeutic response.
Methods: Vaccines were synthesized by solid phase using an Fmoc strategy, where a small molecule toll-like receptor-7 agonist (T7) was conjugated to a monoclonal gastric cancer 7 antigen mono-epitope (T7-MG1) or tri-epitope (T7-MG3). Cytokines were measured in both mouse bone marrow dendritic cells and mouse spleen lymphocytes after exposed to the vaccines.