LXRβ is involved in the control of platelet production from megakaryocytes.

Liver X receptor β (LXRβ), a nuclear receptor involved in important cellular processes such as cholesterol, glucose and fatty acid metabolism, was suggested to be involved in platelet aggregation but its detailed roles are not clear. In the present study, we evaluated the contribution of LXRβ to platelet functions and production. In the systemic collagen-epinephrine thrombosis mouse model, LXRβ-deficient mice showed increased area of blood clots compared with control wide-type littermates.

Abnormal patterns recognition in bivariate autocorrelated process using optimized random forest and multi-feature extraction.

Traditional multivariate control charts are unable to determine the specific abnormal variables as detecting process abnormality. To solve this problem, a new model based on optimized random forest (RF) and multi-feature extraction has been proposed. First, four patterns of process state according to different combinations of abnormal variables are defined.

Gastrodin protects H9c2 cardiomyocytes against oxidative injury by ameliorating imbalanced mitochondrial dynamics and mitochondrial dysfunction.

Gastrodin (GAS) is the main bioactive component of Tianma, a traditional Chinese medicine widely used to treat neurological disorders as well as cardio- and cerebrovascular diseases. In the present study, the protective effects of GAS on H9c2 cells against ischemia-reperfusion (IR)-like injury were found to be related to decreasing of oxidative stress. Furthermore, GAS could protect H9c2 cells against oxidative injury induced by HO.