Publications by authors named "Yu-Wei Tian"
Appleby operation for carcinoma of the body and tail of the pancreas.
J Cancer Res Ther
December 2018
Article Synopsis
- The study evaluates the effectiveness of the Appleby operation in treating pancreatic cancer, analyzing patient outcomes over several weeks and noting key health metrics before and after surgery.
- The operation was performed on 17 patients, resulting in significant pain relief, improved body weight, and enhanced quality of life, despite a notable complication rate of 47.1%.
- The 1-, 2-, 3-, and 5-year survival rates post-surgery were 80.4%, 54.2%, 32.5%, and 16.3%, respectively, indicating that the Appleby operation is a viable option for managing this condition.*
Article Synopsis
- The study aimed to find key genes and pathways in pancreatic ductal adenocarcinoma (PDAC) to help with early diagnosis.
- Researchers analyzed gene expression data from 34 PDAC samples and compared it with 16 healthy samples, identifying 630 upregulated and 1,002 downregulated genes.
- Important findings included specific ribosomal protein genes and spliceosome-related genes that may serve as potential molecular markers for early detection and could be crucial in the disease's progression.
Article Synopsis
- The study investigates the roles of microRNAs miR-34a and miR-217 in hepatocellular carcinoma (HCC), focusing on their expression levels and their potential as indicators of tumor progression and patient prognosis.
- Results showed that both miR-34a and miR-217 were significantly downregulated in HCC tissues, with lower levels linked to worse clinicopathological features such as vascular invasion and advanced disease stage.
- The findings suggest that reduced expression of miR-34a and miR-217 correlates with poorer overall survival for HCC patients, indicating their potential role as tumor suppressors.
Article Synopsis
- Budd-Chari syndrome (BCS) involves disorders affecting the outflow of blood from the liver through the hepatic veins to the inferior vena cava, potentially leading to various complications.
- A 49-year-old man with BCS presented multiple intrahepatic lesions, where tests revealed hepatic vein blockage and benign large regenerative nodules (LRNs) instead of cancerous growths.
- The study suggests that while both benign nodules and liver cancer can occur in BCS patients, there’s limited information available, and decreasing blood flow in the liver may contribute to the formation of these nodules.
Article Synopsis
- SUMOylation and deSUMOylation are important processes that regulate how proteins work, with SENP proteins playing a role in removing SUMO tags from proteins, and their alteration can be linked to cancer progression.
- SENP2 specifically influences the growth of liver cancer cells (HCC) through its interaction with β-catenin, though the detailed mechanism was previously unclear.
- This study reveals that the protein WWOX is essential for the stability of β-catenin in HCC cells and is regulated by SENP2, suggesting that WWOX functions as a crucial modulator of SENP2's tumor-suppressing effects in liver cancer.