Publications by authors named "Yu-Tzu Chien"
Article Synopsis
- The study addresses the challenges of personalized immunotherapy for cancer due to genetic diversity in patients and side effects like immune-related adverse events, emphasizing the need for regulatory immunotherapy.
- Researchers developed a cationic lipo-PEG-PEI complex (LPPC) as a flexible immunoregulatory platform that can adaptively present various proteins to enhance immune responses according to individual patient needs.
- Results demonstrated that the LPPC/MP/CD28 complex effectively activated vital immune responses and eliminated metastatic melanoma cells more efficiently while showing that treatment effects could be altered by using different complexes, highlighting the platform's adaptability.
Background: Circulating mRNA is a less invasive and more easily accessed source of samples for biomedical research and clinical applications. However, it is of poor quality. We explored and compared the ability of two high-throughput platforms for the profiling of circulating mRNA regarding their ability to retrieve useful information out of this type of samples.
View Article and Find Full Text PDFTriplex-forming oligonucleotides (TFOs) are sequence-dependent DNA binders that may be useful for DNA targeting and detection. A sensitive and convenient method to monitor triplex formation by a TFO and its target DNA duplex is required for the application of TFO probes. Here we describe a novel design by which triplex formation can be monitored homogeneously without prelabeling the target duplex.
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