Publications by authors named "Yu-Tseng Chu"
The largest nosocomial outbreak of Middle East respiratory syndrome (MERS) occurred in South Korea in 2015. Health Care Personnel (HCP) are at high risk of acquiring MERS-Coronavirus (MERS-CoV) infections, similar to the severe acute respiratory syndrome (SARS)-Coronavirus (SARS-CoV) infections first identified in 2003. This study described the similarities and differences in epidemiological and clinical characteristics of 183 confirmed global MERS cases and 98 SARS cases in Taiwan associated with HCP.
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- Primary hepatocellular carcinoma (HCC) is a major cancer affecting global health, and understanding new targets for diagnosis and treatment is crucial.
- Niemann-Pick type C2 (NPC2) is found to be highly expressed in normal liver tissue but significantly downregulated in HCC, correlating with worse patient outcomes.
- The study suggests that NPC2 suppresses liver cancer cell growth and ERK1/2 signaling independent of cholesterol levels, positioning AAV-NPC2 as a potential novel treatment for liver cancer.
Objective: Whether peginterferon α and ribavirin combination therapy reduces risk of hepatocellular carcinoma (HCC) or improves survival in patients dual-infected with hepatitis C virus (HCV) and hepatitis B virus (HBV) is unknown. Since it is ethically impossible to conduct a randomised trial to learn the long-term efficacy, we rely upon the large database to explore the effectiveness of combination therapy among dual-infected patients.
Design: Data for this population-based retrospective cohort study were obtained from the treatment programme, Cancer Registry, National Health Insurance and death certification.
Background: It is important to find a comorbidity measure with better performance for use with administrative data. The new method proposed by Elixhauser et al. has never been validated and compared to the widely used Charlson method in the Asia region.
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- A syndromic surveillance system (ED-SSS) was set up in Taiwan in 2004 to enhance early detection of infectious diseases by automatically transmitting patient data from emergency departments to the CDC.
- The development of the system involved consulting healthcare professionals and collaborating with the University of Pittsburgh to analyze real-time data from 189 hospitals over a year.
- The system successfully identified significant trends in illness spikes and ED visit patterns, contributing to improved public health decision-making and pandemic preparedness in Taiwan.