[The role and mechanism of SIRT1 gene in depression].

As a kind of mental illness, depression produces great difficulties in clinical diagnosis and treatment, and has a high disability rate. It is urgent to clarify the mechanism of depression to find potential therapeutic targets and effective clinical treatment methods. As a deacetylase, silent mating type information regulator 2 homolog 1 (SIRT1) is involved in many biological processes such as cell aging, cancer, and cardiovascular disease.

Effect of melamine on potassium currents in rat hippocampal CA1 neurons.

As an industrially synthesized chemical, melamine has been applied in a wide range of areas. However, many questions on the adverse effect and toxicity of melamine have been emerged, recently. In this investigation, the cytotoxicity of melamine on PC12 cells was evaluated.

Effect of alpha-cypermethrin and theta-cypermethrin on delayed rectifier potassium currents in rat hippocampal neurons.

Cypermethrin is a photostable synthetic pyrethroid and the most widely used Type II pyrethroid pesticide. The effects of two different stereoisomers of cypermethrin insecticides, alpha-cypermethrin and theta-cypermethrin, on the delayed rectifier potassium current (IK) in hippocampal neurons of rat, were studied using whole-cell patch clamp technique. Alpha-cypermethrin and theta-cypermethrin decreased the amplitude value of IK, and shifted the steady state activation curve of IK towards negative potential at any concentrations (10(-9) M, 10(-8) M, 10(-7) M).

[Effects of beta-cypermethrin on voltage-gated potassium channels in rat hippocampal CA3 neurons].

The effects of beta-cypermethrin (consisting of alpha-cypermethrin and theta-cypermethrin) on the transient outward potassium current (I(A)) and delayed rectifier potassium current (I(K)) in freshly dissociated hippocampal CA3 neurons of rats were studied using whole-cell patch-clamp technique. The results indicated that alpha-cypermethrin increased the value of I(A) and theta-cypermethrin decreased the value of I(A), though both of them shifted steady activation curve of I(A) towards negative potential. theta-cypermethrin contributed to the inactivation of I(A).