Publications by authors named "Yu-Shi Dai"
Organoid culture has emerged as a forefront technology in the life sciences field. As " micro-organs", organoids can faithfully recapitulate the organogenesis process, and conserve the key structure, physiological function and pathological state of the original tissue or organ. Consequently, it is widely used in basic and clinical studies, becoming important preclinical models for studying diseases and developing therapies.
View Article and Find Full Text PDFDoes the size of the neuroendocrine-carcinoma component determine the prognosis of gallbladder cancer?
Front Endocrinol (Lausanne)
August 2024
Background: Gallbladder mixed neuroendocrine-non-neuroendocrine neoplasm generally consists of a gallbladder neuroendocrine tumor and a non-neuroendocrine component. The World Health Organization (WHO) in 2019 established a guideline requiring each component, both neuroendocrine and non-neuroendocrine, to account for a minimum of 30% of the tumor mass.
Methods: Patients after surgery resection and diagnosed at microscopy evaluation with pure gallbladder neuroendocrine carcinoma (GBNEC), gallbladder mixed adeno-neuroendocrine carcinoma (GBMANEC, GBNEC≥30%), and gallbladder carcinoma mixed with a small fraction of GBNEC (GBNEC <30%) between 2010 and 2022 at West China Hospital of Sichuan University were collated for the analyses.
The importance of evaluating the nutritional status and immune condition prior to surgery has gained significant attention in predicting the prognosis of cancer patients in recent years. The objective of this study is to establish a risk model for predicting the prognosis of gallbladder carcinoma (GBC) patients. Data from GBC patients who underwent radical resection at West China Hospital of Sichuan University (China) from 2014 to 2021 were retrospectively collected.
View Article and Find Full Text PDFBackground: Gallbladder cancer (GBC) is the most prevalent biliary tract tumor characterized by a high incidence of recurrence, even after curative-intent surgery. The object of this systematic review and meta-analysis was to investigate the risk factors related to early recurrence (ER).
Methods: A systematic literature review was conducted in PubMed, Embase, Cochrane Library, and Web of Science to identify published articles up to February 2024.
Article Synopsis
- Intrahepatic cholangiocarcinoma (ICC) is a serious type of cancer that affects the liver, and researchers are trying to understand how the tumor environment interacts with different cells.
- They used a special method to find out which genes are important in the tumor and how cells communicate with each other.
- The study found that certain gene scores related to cancer cells can predict how well patients will do, and they discovered specific ways that certain cells interact, which might help in developing better treatments.
Background: Minimally invasive surgery for intrahepatic cholangiocarcinoma (ICC) remains challenging, especially in advanced patients.
Patient And Method: A 66-year-old male was diagnosed with stage II ICC after a comprehensive evaluation and was scheduled for laparoscopic exploration and left hepatectomy.
Results: The pure laparoscopic left hepatectomy was completed in 240 min, employing a no-touch en bloc technique and lymphadenectomy skeletonization.
Background: Tumor necrosis has been indicated to correlate with dismal survival outcomes of a variety of solid tumors. However, the significance and prognostic value of tumor necrosis remain unclear in gallbladder carcinoma. The aim of this research is to explore the relationships between necrosis with long-term survival and tumor-related biological characteristics of patients with gallbladder carcinoma.
View Article and Find Full Text PDFPancreatic cancer is a malignant disease with a dismal prognosis. While neoadjuvant therapy has shown promise in the treatment of pancreatic cancer, its role remains a subject of controversy among physicians. We aimed to evaluate the benefits of neoadjuvant therapy in patients with resectable and borderline resectable pancreatic cancer.
View Article and Find Full Text PDFObjective: To evaluate the efficiency of laparoscopic surgery in treating recurrent liver tumors vs. conventional open surgery.
Methods: Database searching was conducted in PubMed, the Cochrane Library and EMBASE.
Background: Some studies have pointed out that a wide resection margin can improve the prognosis of intrahepatic cholangiocarcinoma, but some researchers disagree and believe that a wide margin may increase complications. The optimal margin length of intrahepatic cholangiocarcinoma is controversial.
Method: The literature was searched in PubMed, MedLine, Embase, the Cochrane Library, and Web of Science until December 31, 2021, to evaluate the postoperative outcomes of patients with different margin width after resection.
Evidence regarding the optical surgical extent for Bismuth type I/II HCCA is lacking. we aims to evaluate the optimal surgical methods for Bismuth type I/II HCCA. Studies comparing bile duct resection (BDR) and BDR combined with liver resection (BDR + LR) for all types of HCCA patients were searched for analyses, and 14 studies were finally included.
View Article and Find Full Text PDFObjective: To evaluate the consistencies and inconsistencies between distal cholangiocarcinoma (DCCA) and pancreatic ductal adenocarcinoma (PDCA) regarding their biological features and long-term prognosis.
Methods: PubMed, the Cochrane Library, and EMBASE were searched to find comparative studies between DCCA and PDCA. RevMan5.
Article Synopsis
- The study investigates the diagnosis, treatment, and outcomes of gallbladder sarcomatoid carcinoma (GBSC) patients, analyzing data from 50 surgical cases collected between 2000 and 2020.
- Findings reveal a median overall survival of 14.5 months with significant differences in survival rates based on the type of surgery performed, highlighting that radical resection leads to better outcomes compared to palliative surgery.
- The research concludes that due to the aggressive nature of GBSC, timely surgery and postoperative chemotherapy are crucial for improving patient survival, with S-1-based chemotherapy demonstrating higher effectiveness in prolonging recurrence-free survival.