Publications by authors named "Yu-Shan Hu"

Cancer is a significant global health concern, and finding effective methods to treat it has been a focus of scientific research. It has been discovered that the growth, invasion, and metastasis of tumors are closely related to the environment in which they exist, known as the tumor microenvironment (TME). The immune response interacting with the tumor occurring within the TME constitutes the tumor immune microenvironment, and the immune response can lead to anti-tumor and pro-tumor outcomes and has shown tremendous potential in immunotherapy.

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To understand its unprecedented resurgence, we examined the epidemiological, virological, and entomological features of dengue in Guangzhou during 1978-2009. Cases reported to the Guangzhou Centre for Disease Control and Prevention and data from virological and entomological surveillance were analyzed from three periods: 1978-1988, 1989-1999, and 2000-2009. Although cases decreased over time: 6,649 (1978-1988) to 6,479 (1989-1999) to 2,526 (2000-2009), geographical expansion resulted in districts with an average incidence >2.

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Objective: To investigate the value of grOEL gene sequence in phylogenetic analysis and typing of Salmonella.

Methods: The grOEL gene was amplified by PCR, sequenced and analyzed using Bioedit and DNAstar software. The Salmonella strains were identified using PCR-restriction fragment length polymophism (PCR-RFLP).

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Objective: To apply pulse-field gel electrophoresis analysis(PFGE) in analysing a case of food poisoning caused by Vibrio parahaemolyticus.

Methods: PFGE using restriction enzyme Not I was employed in molecular subtyping of thirty strains of V. parahaemolyticus isolated from a case of food poisoning in Guangzhou city and PFGE patterns were analyzed by using BioNumerics Version 4.

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A rapid and accurate method for detection for common pathogenic bacteria in foodborne infections was established by using oligonucleotide array technology. Nylon membrane was used as the array support. A mutation region of the 23S rRNA gene was selected as the discrimination target from 14 species (genera) of bacteria causing foodborne infections and two unrelated bacterial species.

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Synopsis of recent research by authors named "Yu-Shan Hu"

  • - Yu-Shan Hu's recent research focuses on the interplay between the immune system and tumor microenvironment, specifically exploring how the P2X7 receptor affects tumor progression and the immune responses associated with cancer therapies.
  • - Hu conducted extensive epidemiological and virological studies on dengue fever in Guangzhou, highlighting patterns of resurgence and geographical spread of infection over decades, which emphasizes the need for improved surveillance strategies.
  • - The author has also contributed to advancements in microbial diagnostics, particularly in identifying pathogenic bacteria linked to foodborne illnesses through innovative techniques such as PCR-restriction fragment length polymorphism and oligonucleotide array technology.