Publications by authors named "Yu-Rou Wu"
Cell penetrating peptide derived from human eosinophil cationic protein (CPPecp) is a 10-amino-acid peptide containing a core heparan sulfate (HS)-binding motif of human eosinophil cationic protein (ECP). It binds and penetrates bronchial epithelial cells without cytotoxic effects. Here we investigated airway-protective effects of CPPecp in BEAS-2B cell line and mite-induced airway allergic inflammation in BALB/c mice.
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- The study investigated the impact of different molecular weights of inhaled heparins on T helper cell differentiation in a mite allergy model using BALB/c mice.
- Mice were divided into four groups: a control group, a mite sensitized group, and two heparin-treated groups (regular and low molecular weight), with various tests conducted to analyze immune responses.
- Results showed that both heparin treatments significantly reduced serum IgE levels and decreased the expression of key immune markers in the spleen compared to the mite sensitized group, suggesting potential therapeutic effects worth exploring further.