Publications by authors named "Yu-Rong Zhai"
Context: The effects of icariin, a chief constituent of flavonoids from Epimedium brevicornum Maxim (Berberidaceae), on the levels of HIF-1α, HSP-60 and HSP-70 remain unknown.
Objective: To explore the effects of icariin on the levels of HSP-60, HIF-1α and HSP-70 neuron-specific enolase (NSE) and cell viability.
Materials And Methods: PC12 cells were treated with icariin (10, 10 or 10mol/L) for 3 h (1 h before oxygen-glucose deprivation (OGD) plus 2 h OGD).
Icariin Attenuates OGD/R-Induced Autophagy via Bcl-2-Dependent Cross Talk between Apoptosis and Autophagy in PC12 Cells.
Evid Based Complement Alternat Med
September 2016
Article Synopsis
- Icariin (ICA), derived from Epimedium brevicornum Maxim, shows neuroprotective effects, particularly against apoptosis in neurons subjected to oxygen-glucose deprivation and reperfusion (OGD/R).
- The study found that ICA significantly improves cell survival and increases Bcl-2 levels while decreasing pro-apoptotic and autophagy markers like Bax and Beclin-1 in affected PC12 cells.
- These findings indicate that ICA's protective effects involve Bcl-2's regulation of both apoptosis and autophagy, suggesting a complex interplay in neuroprotection.