Synergistic Mutations of and in Familial Tooth Agenesis.

Familial tooth agenesis (FTA), distinguished by developmental failure of selected teeth, is one of the most prevalent craniofacial anomalies in humans. Mutations in genes involved in WNT/β-catenin signaling, including  , , , and are known to cause FTA. However, mutational interactions among these genes have not been fully explored.