Inhibition of TMEM16A improves cisplatin-induced acute kidney injury via preventing DRP1-mediated mitochondrial fission.

Acute kidney injury (AKI) is associated with high morbidity and mortality. Our previous study has demonstrated that TMEM16A, a Ca-activated chloride channel, contributes to renal fibrosis progression in chronic kidney disease. However, whether TMEM16A is involved in AKI is still unknown.

Production of Mesoporous Magnetic Carbon Materials from Oily Sludge by Combining Thermal Activation and Post-Washing.

In this work, the oily sludge (OS) from a local waste oil recycling plant was reused as a precursor for producing porous magnetic carbon composites (CC) by pyrolysis, followed by carbon dioxide activation. Based on the thermogravimetric analysis (TGA) of the OS feedstock, the preparation experiments were performed at 800−900 °C. From the pore analysis of the CC products, it indicated an increasing trend, as the BET surface area greatly increased from about 1.

Preparation and Characterization of Porous Materials from Pineapple Peel at Elevated Pyrolysis Temperatures.

In this work, pineapple peel (PP) was reused as a precursor in biochar (BC) production at elevated temperatures (i.e., 500−900 °C) for residence times of 0−60 min.

Characterization of biochar prepared from biogas digestate.

In the study, the biogas digestate was evaluated as a potential feedstock for preparing biochars at a broad temperature range of 300-900°C. The physico-chemical and pore properties of the resulting biochars (denoted as SDBC, solid digestate biochar), including calorific value (higher heating value), surface area/pore volume/pore size distribution, true density, scanning electron microscopy - energy dispersive X-ray spectroscopy (SEM-EDS) and X-ray powder diffraction (XRD), were studied. It was found that the higher heating values of the SDBC products were on a decreasing trend as pyrolysis temperature increased, but they indicated an increase in true density.

A novel triterpene from Centella asiatica.

A novel triterpene, 2alpha,3beta,20,23-tetrahydroxyurs-28-oic acid (1), was isolated from the aerial part of Centella asiatica. Its structure was elucidated by spectroscopic methods, including 2D-NMR spectra. It displayed no activity against Hela and A549 cell lines at concentrations of 10 and 30 microg/mL, respectively.

[Studies on chemical constituents in herb of Centella asiatica].

Objective: To study the chemical constituents from Centella asiatica.

Method: Chemical constituents were isolated by repeated column chromatography (Toyopearl HW-40C and HPLC) and their structures were elucidated on the basis of spectroscopic method.

Result: Five compounds were identified as: docosyl ferulates (1), bayogenin (2), 3beta-6beta-23-trihydroxyolean-12-en-28-oic acid (3), 3beta-6beta-23-trihydroxyurs-12-en-28-oic acid (4), D-gulonic acid (5).

[Determination of aisaticoside in Centella asiatica extract by HPLC-ELSD].

Objective: A HPLC-ELSD method was established for the simultaneous quantitative determination of asiaticoside in Centella asiatica extract.

Method: The column was packed with 5 m HIQ C18 stationary phase. The mobile phase consisted of acetonitrile-water, eluted in gradient mode.