Publications by authors named "Yu-Qing Shan"
Background: With the increase of age, multiple physiological functions of people begin gradually degenerating. Regardless of natural aging or pathological aging, the decline in cognitive function is one of the most obvious features in the process of brain aging. Brain aging is a key factor for several neuropsychiatric disorders and for most neurodegenerative diseases characterized by onset typically occurring late in life and with worsening of symptoms over time.
View Article and Find Full Text PDFPurpose: To analyze the safety and feasibility of computed tomography (CT)-guided thermal ablation of multiple pulmonary nodules combined with intraoperative biopsy.
Methods: The data of 431 patients with 540 lung nodules undergoing CT-guided biopsy or ablation were retrospectively analyzed. Biopsy-only group (A): 107 patients (107 lesions) received CT-guided percutaneous lung biopsy only; Ablation-only group (B): 117 cases (117 lesions) only received CT-guided thermal ablation; Single focal ablation combined with biopsy group (C): 103 patients (103 lesions) received CT-guided thermal ablation combined with intraoperative immediate biopsy; Multifocal ablation combined with biopsy group (D): 104 patients (213 lesions) received CT-guided thermal ablation combined with intraoperative biopsy.
Article Synopsis
- Blood-based proteomic analysis is commonly used to find disease biomarkers, but it doesn't fully capture changes in nerve cells in Alzheimer's disease (AD).
- This study employed a multi-omics approach, combining single-nuclei RNA sequencing and serum proteomic data to identify potential AD biomarkers, resulting in the detection of 10 significant candidates.
- Four key biomarkers (NEBL, EPB41L2, FGD4, and MARCKS) were confirmed to be related to the actin cytoskeleton regulation, which is linked to synaptic loss in AD, offering new targets for treatment and prognosis.