Publications by authors named "Yu-Qing Cheng"
Background: Early adenocarcinoma mixed with a neuroendocrine carcinoma (NEC) component arising in the gastroesophageal junctional (GEJ) region is rare and even rarer in young patients. Here, we report such a case in a 29-year-old Chinese man.
Case Summary: This patient presented to our hospital with a 3-mo history of dysphagia and regurgitation.
Objective: To investigate the clinicopathological and prognostic significance of intestinal metaplasia (IM) in endoscopically resected early gastric carcinoma (EGC).
Methods: Altogether 136 consecutive cases with EGC resected by endoscopic submucosal dissection over 5 years were included and divided into the early gastric cardiac (EGCC; n = 60) and non-cardiac carcinoma (EGNCC; n = 76) groups. Goblet cell IM and subtypes were determined with histology and immunostaining.
Article Synopsis
- Prolyl endopeptidase (PREP) is linked to various health issues like inflammation and metabolic dysfunctions, particularly in conditions like metabolic dysfunction-associated fatty liver disease (MAFLD).
- The study used a high-fat diet (HFD) mouse model to observe changes in the PREP system over time and assessed the effects of the PREP inhibitor KYP-2047 on the condition.
- Results showed that increased PREP activity worsens liver damage and inflammation in MAFLD, while KYP-2047 improved liver health and metabolism, suggesting it could be a potential treatment for the disease.
Article Synopsis
- Macrophages are important immune cells that help defend against disease and maintain health, and their dysfunction is linked to conditions like liver fibrosis.
- The study highlights that knocking out the prolyl endopeptidase (PREP) gene in macrophages alters their gene expression and worsens liver fibrosis in a nonalcoholic steatohepatitis (NASH) model.
- PREP acts as a transcriptional coregulator in macrophages, interacting with the transcription factor PU.1 and influencing the expression of genes related to fibrosis, indicating a protective role against liver damage.
In early gastric cancer (EGC) patients, lymph node metastasis (LNM) risk assessment is particularly important for the selection of surgical methods. In this study, we investigated the correlation between gastritis cystica profunda (GCP) and the risk of LNM in EGC. From January 2014 to December 2019, EGC patients who underwent curative radical gastrectomy were enrolled in this study.
View Article and Find Full Text PDFEstablishing a rabbit model of perianal fistulizing Crohn's disease.
World J Gastroenterol
April 2022
Background: Crohn's disease (CD) is a chronic nonspecific intestinal inflammatory disease. The aetiology and pathogenesis of CD are still unclear. Anal fistula is the main complication of CD and is a difficult problem to solve at present.
View Article and Find Full Text PDFObjective: To investigate histopathologic changes of muscularis mucosae (MM) and submucosa in the gastric cardia.
Methods: We performed a histopathology study of 50 distal esophagectomies with proximal gastrectomies for esophageal squamous cell carcinoma as the study (non-cancerous cardiac) group and 60 gastrectomies for early gastric cardiac carcinoma as the cancer group. The gastroesophageal junction was defined as the distal end of squamous epithelium, multilayered epithelium, or deep esophageal glands or ducts.
[Clinicopathological Observation of Primary Renal Non-Hodgkin's Lymphoma--A Report of Two Cases].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
February 2019
Objective: To investigate the clinicopathological and immunohistochemical features as well as diagnosis, differential diagnosis,treatment and prognosis of patients with primary renal non-hodgkin's lymphoma (PRNHL).
Methods: Clinical data of 2 patients with PRNHL from January 2013 to October 2017 were retrospectively analyzed.
Results: One of the two male patients PRNHL aged 51 years old, admitted to hospital for swelling and pain in the right waist, B-ultra sonic examination showed a very solid upper right renal space occupying lesion.
Objective: To investigate risk factors of lymph node metastasis (LNM) in early gastric carcinoma (EGC) in four tertiary medical centers in Jiangsu Province, China.
Methods: Among 10 097 consecutive combined gastric cancer radical resections, 1903 EGC were identified and reviewed, 283 excluded and 1620 included in the study. All pathological and some endoscopic reports were reviewed for patients' characteristics, tumor location, gross features, and the number of lymph nodes retrieved and involved.