Publications by authors named "Yu-Qin Cheng"
Article Synopsis
- Gastric intestinal metaplasia (GIM) is a significant precursor to gastric cancer, and the traditional Chinese medicine Huangqi Jianzhong decoction (HQJZ) shows promise for treating patients with cold intolerance, though the underlying mechanisms are unclear.
- The study aimed to understand how HQJZ affects GIM through the gut microbiota‒thyroid axis using a rat model, assessing tissue lesions and serum metabolites.
- Results revealed that HQJZ improved gastric and thyroid conditions, enhanced cold tolerance, increased beneficial gut bacteria, and reduced harmful metabolites, indicating its potential therapeutic mechanisms involving butyric acid.
Article Synopsis
- RNA silencing is a key defense mechanism in plants against viral infections, but viruses like apple stem grooving virus (ASGV) use RNA-silencing suppressors (RSSs) to counteract this defense.
- The helicase motif of ASGV's replicase functions as an RSS by inhibiting RNA silencing, but the pear transcription factor PbRAV1 can reduce its effectiveness by binding to it and decreasing its ability to bind siRNA.
- PbRAV1 also impacts another RSS from a different virus, demonstrating its dual role in defending against viral infections, while ASGV can manipulate other host proteins to enhance its own suppressive activity.
Grapevine leafroll-associated virus 1 (GLRaV-1) is a major pathogen associated with grapevine leafroll disease. However, the molecular mechanisms underlying GLRaV-1 interactions with plant cells are unclear. Using infiltration-mediated RNA-silencing assays, we demonstrated that GLRaV-1 p24 protein (p24) acts as an RNA-silencing suppressor (RSS), inhibiting local and systemic RNA silencing.
View Article and Find Full Text PDFGrapevine leafroll-associated virus 3 (GLRaV-3) is widely spread in China. Here we report, for the first time, the complete nucleotide sequence of the Chinese isolate (LN) of GLRaV-3. The 18,563-nt genomic RNA is the largest of the GLRaV-3 genomes reported to date, with a 5' untranslated region of 802 nt.
View Article and Find Full Text PDFSymptom development of a plant viral disease is a result of molecular interactions between the virus and its host plant; thus, the elucidation of specific interactions is a prerequisite to reveal the mechanism of viral pathogenesis. Here, we show that the chloroplast precursor of ferredoxin-5 (Fd V) from maize (Zea mays) interacts with the multifunctional HC-Pro protein of sugar cane mosaic virus (SCMV) in yeast, Nicotiana benthamiana cells and maize protoplasts. Our results demonstrate that the transit peptide rather than the mature protein of Fd V precursor could interact with both N-terminal (residues 1-100) and C-terminal (residues 301-460) fragments, but not the middle part (residues 101-300), of HC-Pro.
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