Traditional Chinese Medicine in Cancer Care: An Overview of 5834 Randomized Controlled Trials Published in Chinese.

Background: Traditional Chinese medicine (TCM) is widely integrated into cancer care in China. An overview in 2011 identified 2384 randomized and non-randomized controlled trials (RCTs, non-RCTs) on TCM for cancer published in the Chinese literature. This article summarizes updated evidence of RCTs on TCM for cancer care.

[Spatial autocorrelation analysis of land use and ecosystem service value in Maduo County, Qinghai Province, China at the grid scale].

Research on the spatial quantitative evaluation of land use and ecosystem service value in the source region of the Yellow River is of great significance for ensuring the ecological security of the river basin. Taking Maduo County in the source region of the Yellow River as an example, based on a 3 km × 3 km grid unit, the spatial autocorrelation method was applied to construct an evaluation model of ecosystem service value. The spatial autocorrelation pattern characteristics of Maduo County in 2015 was quantitatively evaluated, and the spatial information of ecosystem service value was visually expressed.

The effects of Chinese herbal medicines for treating diabetic foot ulcers: A systematic review of 49 randomized controlled trials.

Objective: To assess the effects and associated risks of Chinese herbal medicine (CHM) for diabetic foot ulcer (DFU).

Methods: We systematically searched seven electronic databases for randomized controlled trials (RCTs) about Chinese herbal medicines for treating diabetic foot ulcers. The methodological quality of RCTs was assessed by the Cochrane risk of bias tool.

Radioprotection of 4-hydroxy-3,5-dimethoxybenzaldehyde (VND3207) in culture cells is associated with minimizing DNA damage and activating Akt.

Vanillin is a naturally occurring compound and food-flavoring agent with antioxidant and antimutagenic activities. In present study, we explored the radioprotective effect of a novel vanillin derivative VND3207 (4-hydroxy-3,5-dimethoxybenzaldehyde). VND3207 has a much higher potential in scavenging hydroxyl radical and superoxide radical than vanillin as indicated in the ESR spin-trapping measurement, and it can effectively protect plasmid DNA against 10-50 Gy gamma-ray induced breaks in vitro at the concentrations as low as 10-20 microM.

Induction of apoptosis and autophagic cell death by the vanillin derivative 6-bromine-5-hydroxy-4-methoxybenzaldehyde is accompanied by the cleavage of DNA-PKcs and rapid destruction of c-Myc oncoprotein in HepG2 cells.

Autophagy is a regulated lysosomal pathway involving the bulk degradation of cytoplasmic contents, and is an emerging attractive therapeutic approach for treating cancers. In the present study, we demonstrates that bromovanin (6-bromine-5-hydroxy-4-methoxybenzaldehyde), a vanillin derivative, exhibits a potent antiproliferative effect on a broad spectrum of cancer cell lines, but it induces apoptosis with a large variation in extent on different cancer cell lines. Ultrastructural observation in transmission electron microscopy reveals that autophagy is another type of cell death induced by bromovanin in HepG2 cells.

Vanillin derivative 6-bromine-5-hydroxy-4-methoxybenzaldehyde-elicited apoptosis and G2/M arrest of Jurkat cells proceeds concurrently with DNA-PKcs cleavage and Akt inactivation.

Vanillin, a naturally occurring food component, has been reported to have anti-mutagenic and anti-metastatic potentials, and to inhibit DNA-PKcs activity. However, vanillin itself exhibits very weak antiproliferative activity. We explored the effects of bromovanin (6-bromine-5-hydroxy-4-methoxybenzaldehyde), a novel vanillin derivative, on survival and cell-cycle progression of human Jurkat leukemia cells.