Publications by authors named "Yu-Qi Lai"
[Mechanism of regulation of CNP rat model by oxalis decoction via cGAS-STING signaling pathway].
Zhonghua Nan Ke Xue
December 2023
Objective: To investigate the therapeutic mechanism of oxalis decoction on CNP rats by regulating cGAS-STING signaling pathway.
Methods: Thirty specific pathogen-free SD male rats were randomly divided into normal control group (NC), model control group (MC), and oxalis decoction group (OD),with 10 rats in each group.The left and right anterior abdominal lobes of each group were surgically exposed.
Objective： To explore the mechanism of Miao ethnicity medicine formula of Oxalis corniculata against chronic non-bacterial prostatitis. Methods: The rat model of chronic abacterial prostatitis was induced by stimulation with 2% sterile carrageenan solution. After modeling, the rats were randomly divided into two groups, Model control group (Model group) and oxalis group.
View Article and Find Full Text PDFObjective: To explore the potential mechanism of action of levocarnitine in the treatment of epididymitis based on network pharmacology and experimental research.
Methods: The target proteins related to epididymitis and levocarnitine were retrieved through multiple databases, and the common targets were obtained using Venny software. The protein-protein interactions were obtained using the STRING database.
Objective: This study aimed to investigate the mechanism of Xiaoluanwan(II) in treating lipopolysaccharide(LPS)-induced epididymitis and its impact on the NLRP3 inflammasome.
Methods: The murine epididymitis model was established through local injection of LPS. The study included a control group (n=5), a model group (n=5), a model group treated with Xiaoluanwan(II) (Ⅱ) (n=5), and a saline group treated with Xiaoluanwan(II) (n=5).
Objective: To explore the potential action mechanisms of Xiaoluowan (II) (XLW-II) in the treatment of epididymitis through a network pharmacology approach.
Methods: We searched various databases for relevant targets associated with epididymitis and XLW-II and obtained the common targets of epididymitis and XLW-II on the Venny platform. We acquired the protein-protein interactions (PPI) using the STRING data and had them visualized with the Cytoscape software.
Article Synopsis
- - The study aimed to evaluate the effectiveness and safety of low-intensity extracorporeal shockwave therapy (Li-ESWT) in treating erectile dysfunction (ED) in 26 patients, administering treatments over six weeks while monitoring symptoms and side effects.
- - Results showed significant improvements in IIEF-5 and EHS scores after the treatment, particularly peaking at six months, although some scores declined by the twelfth month but remained above baseline levels.
- - The treatment had a low occurrence of adverse effects, mainly mild issues like itching and pain, indicating Li-ESWT is a promising option for improving ED symptoms safely.