Propofol improves survival in a murine model of sepsis via inhibiting Rab5a-mediated intracellular trafficking of TLR4.

Background: Propofol is a widely used anesthetic and sedative, which has been reported to exert an anti-inflammatory effect. TLR4 plays a critical role in coordinating the immuno-inflammatory response during sepsis. Whether propofol can act as an immunomodulator through regulating TLR4 is still unclear.

Rapid determination of sulfonamides in chicken using two-dimensional online cleanup mode with three columns coupled to liquid chromatography-tandem mass spectrometry.

A novel method based on online cleanup mode combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) was established. After an automated sample cleanup system with aqueous gel column, sulfonamides in chicken were detected in multiple reaction monitoring (MRM) mode. The total run time of the system, which included automated extraction, analytical chromatography and re-equilibration, was within 30 min.

Development of an EHR system for sharing - a semantic perspective.

Building up Electronic Health Record (EHR) systems is considered a promising approach to improve health care quality in China. In order to meet the challenges of EHR semantic interoperability, we present a HL7 Clinical Document Architecture (CDA) R2 based EHR system prototype developed for Guangdong Hospital of Traditional Chinese Medicine (GDHTCM). In particular, we demonstrate how semantic technologies are leveraged to benefit EHR users from enabling semantic search against an EHR repository.