Severity of spontaneous echo contrast in the jugular vein associated with ischemic stroke.

This study evaluated the relationship between spontaneous echo contrast (SEC) in the internal jugular vein (JV), atherosclerotic markers and ischemic stroke. One hundred twenty patients with acute ischemic stroke and 120 controls were recruited. SEC score correlated with plasma level of fibrinogen (coefficient: 0.

Relationship between acute stroke outcome, aspirin resistance, and humoral factors.

Background: The relationship between biochemical aspirin resistance (AR) and functional outcome of acute ischemic stroke is uncertain.

Methods: Prospectively, 269 patients with acute ischemic stroke were recruited. Their responsiveness to aspirin was evaluated by platelet function analyzer (PFA-100).

A small-molecule-controlled system for efficient pseudotyping of prototype foamy virus vectors.

Foamy virus (FV) vector systems have recently demonstrated their power as efficient gene transfer tools for different target tissues. Unfortunately, FVs cannot be naturally pseudotyped by heterologous viral glycoproteins due to an unusual particle morphogenesis involving a FV Env-dependent particle release process. Therefore, current FV vector systems are constrained to the broad host cell range provided by the cognate viral glycoprotein.

Transcription activation of myostatin by trichostatin A in differentiated C2C12 myocytes via ASK1-MKK3/4/6-JNK and p38 mitogen-activated protein kinase pathways.

Myostatin is a negative regulator of skeletal muscle mass. The pathways employed in modulating myostatin gene expression are scarcely known. We aimed to determine the signaling pathway of myostatin induction by a histone deacetylase (HDAC) inhibitor-trichostatin A (TSA) in differentiated C(2)C(12) myocytes.

[The adaptation process and behavioral responses of a patient with peripheral arterial occlusive disease who has undergone amputation].

The purpose of this study was to explore the adaptation and behavioral responses of an 85 year-old woman who suffered from gangrene related to peripheral arterial occlusive disease and finally underwent lower limb amputation. The field method was adopted. Records of the patient's behaviors were collected by observation and interviews.