Publications by authors named "Yu-Nong Xie"
Article Synopsis
- Sorafenib is a key drug for treating advanced hepatocellular carcinoma (HCC) but shows reduced effectiveness due to ferroptosis suppression in resistant cases.
- Long noncoding RNA URB1-AS1 is found to be highly expressed in sorafenib-resistant HCC and helps reduce ferroptosis, leading to worse outcomes for patients.
- Targeting URB1-AS1 could potentially enhance the effectiveness of sorafenib treatment, offering a new strategy to combat resistance in HCC.
The liver plays central roles in coordinating different metabolic processes, such as the catabolism of amino acids. In this study, we identify a loss of tyrosine catabolism and a concomitant increase in serum tyrosine levels during liver cancer development. Liver cells with disordered tyrosine catabolism, as exemplified by the suppression of a tyrosine catabolic enzyme 4-hydroxyphenylpyruvate dioxygenase (HPD), display augmented tumorigenic and proliferative potentials.
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