Publications by authors named "Yu-Ni Zhang"
Succinate aggravates intestinal injury in mice with necrotizing enterocolitis.
Front Cell Infect Microbiol
October 2023
Article Synopsis
- Necrotizing enterocolitis (NEC) is a serious gastrointestinal condition mainly affecting premature infants, and the study focuses on the role of succinate, a metabolite, in its pathogenesis.
- Through analysis of fecal samples from neonates and mouse models, the study found that succinate levels were significantly higher in NEC cases compared to non-NEC cases, indicating a potential link between succinate and changes in gut bacteria.
- Increased levels of succinate were shown to worsen weight gain, intestinal damage, and mortality in mice, along with notable shifts in inflammatory cytokine gene expression, suggesting that succinate may play a detrimental role in NEC development.