Inhibition of LOX-1 alleviates the proinflammatory effects of high-mobility group box 1 in keratitis.

Aim: To investigate the inflammatory amplification effect of high-mobility group box 1 (HMGB1) in () keratitis and the relationship between lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) and HMGB1 in keratitis immune responses.

Methods: Phosphate buffer saline (PBS), and Boxb were injected into BALB/c mice subconjunctivally before the corneas were infected with RAW264.7 macrophages and neutrophils were pretreated with PBS and Boxb to determine the HMGB1 inflammatory amplification effects.

Form-deprivation myopia induces decreased expression of bone morphogenetic protein-2, 5 in guinea pig sclera.

Aim: To identify the presence of various bone morphogenetic proteins (BMPs) and their receptors in normal sclera of human, rat and guinea pigs, and to determine whether their expression changed with form-deprivation myopia (FDM) in guinea pig sclera.

Methods: The expression of BMPs and BMP receptors were detected using reverse transcription polymerase chain reaction (RT-PCR) and immunofluorescence. Two-week-old guinea pigs were monocularly form-deprived with a translucent lens.

[Clinical observation of visual quality after implantation of toric intraocular lens].

Objective: To observe the visual quality after implantation of Acrysof toric intraocular lens (IOL) in cataract patients.

Methods: Eighty eyes (60 patients) had implantation of Acrysof toric IOL in our hospital between Oct. 2009 and Sep.