Publications by authors named "Yu-Ming Qi"
Article Synopsis
- Organelles play a crucial role in cellular processes, and understanding how targeting them can affect anti-tumor activity is challenging.
- The study focused on synthesizing naphthalimide derivatives modified with either amide or acylhydrazine, finding that some amide variants showed higher cytotoxicity than their acylhydrazine counterparts.
- Through fluorescence imaging and other analyses, it was determined that targeting the nucleus enhances cytotoxic effects by improving DNA binding and causing cell cycle arrest in the S phase, suggesting pathways for future anti-tumor drug development.
