Dynamic selection in metallo-organic cube Cd L conformations induced by perfluorooctanoate encapsulation.

Metallo-organic cages possess flexibility comparable to that of biological receptors and can alter their conformations to better accommodate guest species due to the dynamic reversibility of the coordination bond. Induced fit is widely accepted involving conformation change of the host, while few definitive examples are related to conformation selection. Herein, we report the generation of metallo-organic cube Cd L with two coexisting conformations, which have been fully confirmed by NMR, ESI-MS and single-crystal X-ray diffraction analysis.

Metal-ion-determined geometrical configurations of metallo-cages with different emission properties.

The formation of metallo-cages is affected by a variety of factors such as the ligands, metals, and anions, among which the impact of metals with different binding capacities is particularly important, but has rarely been studied in three-dimensional metallo-cages. Herein, we report the design of truxene-centered terpyridine ligands and the self-assembly of a series of tetrameric metallo-cages. The utilization of metal ions with strong (Zn, Fe) or weak (Cd) binding strength afforded 3D metallo-cages with low symmetry or highly symmetric metallo-tetrahedra, respectively, possessing totally different geometrical configurations.

A truncated triangular prism constructed by using imidazole-terpyridine building blocks.

The construction of low-symmetry topological supramolecular structures using bistable building blocks remains challenging. We report an unusual truncated triangular prismatic cage with symmetry using a ligand with both - and -configurations upon coordination with metal. This work provides new ideas and methods for the future synthesis of low-symmetry topological supramolecules.

Anion-Regulated Hierarchical Self-Assembly and Chiral Induction of Metallo-Tetrahedra.

The precise control over hierarchical self-assembly of superstructures relying on the elaboration of multiple noncovalent interactions between basic building blocks is both elusive and highly desirable. We herein report a terpyridine-based metallo-cage T with a tetrahedral motif and utilized it as an efficient building block for the controlled hierarchical self-assembly of superstructures in response to different halide ions. Initially, the hierarchical superstructure of metallo-cage T adopted a hexagonal close-packed structure.

[Lipoprotein lipase gene mutations and the risk of cardiovascular diseases in children with obesity].

Objective: To inquire into the relationship between lipoprotein lipase (LPL) gene D9N, N291S and S447X polymorphisms and the development of cardiovascular diseases in children with obesity.

Methods: The polymerase chain reaction (PCR) and restriction fragment length polymorphism (RLFP) techniques were used to detect three common mutations of LPL gene exon D9N, N291S and S447X in 157 obese children and 175 normal controls. Plasma lipid and lipoprotein levels between children with different genotypes were compared.