Publications by authors named "Yu-Min H"
Backgruound: Despite diabetes mellitus (DM) and pancreatitis being known risk factors for pancreatic cancer, patients with these conditions are not included in pancreatic cancer screening due to the low incidence of pancreatic cancer in these populations. This study aimed to determine the high-risk subgroup of patients with diabetes and pancreatitis that would benefit from pancreatic cancer screening.
Methods: A nested case-control study was conducted using data from the National Health Information Database of the Korean National Health Insurance Service.
Background: Achieving optimal glucose control is essential in the management of type 2 diabetes (T2D). This study aimed to evaluate the effectiveness and safety of oral quadruple combination therapy for the treatment of T2D.
Methods: This meta-analysis reviewed original research on oral quadruple combination therapy for T2D, including both experimental and observational studies with a minimum duration of 12 weeks.
Background And Objectives: Despite the mechanistic potential of sodium-glucose cotransporter 2 inhibitor (SGLT2i) to improve neurologic outcomes, the efficacy of SGLT2i in neurodegenerative disorders among patients with type 2 diabetes is not well established. This population-based cohort study aimed to investigate the association of SGLT2i use with risks of incident dementia and Parkinson disease (PD) in patients with type 2 diabetes.
Methods: This was a retrospective examination of data from a cohort of 1,348,362 participants with type 2 diabetes (≥40 years), who started antidiabetic drugs from 2014 to 2019, evaluated using the Korean National Health Insurance Service Database.
Data on epidemiology and secular trend in primary hyperparathyroidism (PHPT) in adults are relatively limited in Asian countries. This study aims to provide an overview of the secular trends in incidence, clinical characteristics, and treatment patterns of PHPT in South Korea. We used Korea's National Health Insurance Claim database (2005-2020) to identify newly diagnosed PHPT cases.
View Article and Find Full Text PDFArticle Synopsis
- The study examined the link between SGLT2 inhibitors and fracture risk in elderly women with type 2 diabetes who just started taking new diabetes medications.
- Data was analyzed from a nationwide cohort in South Korea, focusing on women aged 65 and older, specifically those not prescribed certain other diabetes drugs.
- Results indicated that SGLT2i users had a higher rate of vertebral fractures compared to non-users, suggesting caution when prescribing these medications to older women due to potential fracture risks.
Article Synopsis
- Myasthenia gravis (MG) is an autoimmune disorder that leads to muscle weakness and increased fatigue, which may contribute to a higher risk of fractures due to factors like restricted mobility and corticosteroid use.
- A study analyzed claims data from the Korean National Health Insurance Service, finding that patients with MG had a significantly higher incidence of major osteoporotic fractures compared to matched controls, with a greater risk observed in younger individuals and men.
- Key factors increasing fracture risk in MG patients included older age, female gender, high doses of glucocorticoids, use of immunosuppressants, and a history of previous fractures, highlighting the need for preventive measures for this population.
Background: Although hypertension is a critical risk factor for dementia, the association between primary aldosteronism (PA) and dementia has been scarcely reported. We aimed to investigate whether the risk of dementia in patients with PA was elevated compared with patients with essential hypertension (EH).
Methods: From the National Health Insurance Claim database in Korea (2003-2017), 3,687 patients with PA (adrenalectomy [ADX], n = 1,339, mineralocorticoid receptor antagonist [MRA] n = 2,348) with no prior dementia were age- and sex-matched at a 1:4 ratio to patients with EH (n = 14,741).
Article Synopsis
- The study aimed to evaluate the causes and symptoms of primary spontaneous pneumomediastinum (PSPM) and to identify factors linked to recurrent spontaneous pneumomediastinum (RSPM) among patients.
- A total of 237 patients, predominantly young men with an average age of 23.4, were analyzed from 2010 to 2021, revealing that acute chest pain and cough were the most common symptoms and triggers of PSPM, with a 4.6% recurrence rate.
- The research found a significant correlation between asthma and RSPM, indicating that asthmatic patients have a higher risk of recurrence, and emphasized the importance of informing these patients about their risk.
Background: There is a lack of studies evaluating the association between thrombus volume and density of deep vein thrombosis (DVT) and pulmonary embolism (PE).
Purpose: To assess the clinical value of thrombus volume and density for prediction of PE in patients with DVT.
Material And Methods: Among the patients with DVT, those without PE were classified as the "DVT-only group" and those with PE were classified as the "DVT-PE group.
Article Synopsis
- - The study analyzed the link between gamma-glutamyl transferase (GGT) levels and hip fracture risk in middle-aged women using data from the Korean National Health Insurance Service over 13 years, excluding individuals with chronic liver issues or heavy drinking.
- - Out of 127,141 women aged 50 and older, 2,758 experienced hip fractures during the follow-up, revealing that the highest GGT levels corresponded to a greater incidence of fractures.
- - An increase of one log-unit in GGT was found to raise hip fracture risk by 17%, showing that higher GGT is associated with increased fracture risk in postmenopausal women, regardless of their alcohol consumption and liver health.
Article Synopsis
- * Out of 2,819 patients with VF codes, 995 met at least one definition, and 594 were confirmed to have true fractures through medical records and imaging.
- * The sensitivity and positive predictive value (PPV) of the definitions were found to be 62.5% and 59.7%, respectively, indicating the definitions' validity for identifying osteoporotic VFs in claims data.
Purpose: This study examined the prevalence of metabolic syndrome (MetS) in South Korean children and adolescents by gender and age and analyzed gender-specific factors associated with MetS.
Methods: This study used data on children aged 10-18 years from the Korea National Health and Nutrition Examination Survey (KNHANES) from 2010 to 2015. Analyses included descriptive statistics, the independent t-test, the test, and univariate logistic regression analysis (<.
[Figure: see text]. Increased risk of atrial fibrillation was reported in patients with primary aldosteronism. However, data are limited regarding the time-dependent risk of atrial fibrillation in surgically or medically treated primary aldosteronism.
View Article and Find Full Text PDFThe aim of this paper was to investigate the effect of total polysaccharide from Balanophora henryi(TBP) on alcoholic liver disease(ALD) and explore the possible mechanism. C57 BL/6 N mice were randomly divided into 4 groups: pair-feeding group, alcohol-feeding model group, model+TBP group and TBP drug control group. The Gao-binge method was used to prepare the chronic ALD model, and at the same time, 400 mg·kg~(-1) TBP was given for interventional therapy.
View Article and Find Full Text PDFBackground: Pyogenic liver abscess (LA) is difficult to distinguish from intrahepatic mass-forming cholangiocarcinoma (IMCC) in the emergency department (ED). We evaluated the predictive ability of white blood cells (WBC) and C-reactive protein (CRP) levels, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and delta neutrophil index (DNI) in LA and IMCC in the ED.
Methods: Forty patients with IMCC between January 2011 and December 2018 were included in this study.
Purpose: The study aimed to investigate whether isocitrate dehydrogenase 1 (IDH1) mutation status in gliomas can be estimated by volume-based histogram analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).
Materials And Methods: Preoperative DCE-MRI data of 85 pathologically confirmed glioma patients including 33 carrying IDH1 mutant type (IDH1) and 52 with IDH1 wildtype (IDH1) were reviewed in a retrospective approach. Regions of interest (ROI) covering entire tumor volume were manually delineated using O.
Background: β-blockers (BBs) are considered primary therapy in stable heart failure (HF) with reduced ejection fraction (HFrEF) without atrial fibrillation (AF); evidence-based benefits of BB on outcome have been documented. However, BBs have not been shown to improve mortality or reduce hospital admissions in HF patients with AF. This study assessed the relationship between BBs at discharge and relevant clinical outcomes in acute heart failure (AHF) patients with AF.
View Article and Find Full Text PDFSeasonal variation in acute post-cataract surgery endophthalmitis incidences in South Korea.
J Cataract Refract Surg
December 2019
Purpose: Previous studies have reported conflicting results on the influence of seasons on post-cataract surgery endophthalmitis incidences. This study aimed to investigate the seasonality associated with the incidence of postoperative endophthalmitis, and to evaluate its association with climate variables in South Korea.
Setting: South Korea.
Purpose: To assess the nationwide rate of acute postoperative endophthalmitis (APE) after cataract extraction in Korea and to evaluate potential risk factors thereof.
Materials And Methods: Nationwide insurance claims data from July 2014 to June 2017 were reviewed. All patients with phacoemulsification or extracapsular/intracapsular cataract extraction were included.
Background: The safety and efficacy of immediate multivessel coronary intervention (MVI) remain controversial in patients with ST-elevation myocardial infarction (STEMI) and multivessel disease (MVD). This study aimed to investigate the clinical outcomes of immediate MVI compared with culprit-vessel intervention only (CVI-O) in diverse subgroups with STEMI and MVD.
Patients And Methods: We compared immediate MVI (n=260) and CVI-O (n=931) regarding 1-year major adverse cardiac event rates for cardiac death, recurrent myocardial infarction (MI), and repeat revascularization in 1191 STEMI patients with MVD using data from the Korea Acute Myocardial Infarction-National Institutes of Health registry (2011-2015).
Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism.
Endocrinol Metab (Seoul)
December 2018
Background: Increasing evidence supports interplay between aldosterone and parathyroid hormone (PTH), which may aggravate cardiovascular complications in various heart diseases. Negative structural cardiovascular remodeling by primary aldosteronism (PA) is also suspected to be associated with changes in calcium levels. However, to date, few clinical studies have examined how changes in calcium and PTH levels influence cardiovascular outcomes in PA patients.
View Article and Find Full Text PDFPurpose: Organophosphates, commonly used in agricultural pesticides, pose high risks and incidences of poisoning. In the present study, we investigated the relative risk and clinical severity, including laboratory results, of non-oral route poisoning (NORP) patients, compared to oral route poisoning (ORP) patients.
Materials And Methods: A single institutional toxicology database registry was utilized to gain information on clinical laboratory results on organophosphate poisoning patients who visited the emergency department (ED) between January 2000 and October 2016.
Background And Aims: The criteria for a standard polypectomy technique for complete removal of small colorectal polyps has not yet been established. This study aimed to compare the complete resection rate of hot snare polypectomy (HSP) with that of EMR for small, sessile, or flat polyps.
Methods: Patients with 5- to 9-mm non-pedunculated colorectal polyps were prospectively randomized to the HSP or EMR group.