Publications by authors named "Yu-Meng He"
Int J Clin Exp Pathol
July 2020
Article Synopsis
- Methyl-CpG-binding protein 2 (MeCP2) modulates gene expression by binding to methylated CpG sites, and this study investigates its role in human gastric adenocarcinoma.
- The researchers employed a combination of expression microarray and ChIP-seq to identify MeCP2's gene targets, finding 5,684 binding peaks and establishing a genome-wide binding pattern.
- The findings suggest that MeCP2 functions as a versatile transcriptional regulator, with its effects on gene expression being influenced by various factors like the microenvironment and the methylation status of the binding sites.
