Publications by authors named "Yu-Mei Zeng"

Increased vascular permeability facilitates metastasis. Cancer-secreted exosomes are emerging mediators of cancer-host crosstalk. Epstein-Barr virus (EBV), identified as the first human tumor-associated virus, plays a crucial role in metastatic tumors, especially in nasopharyngeal carcinoma (NPC).

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Article Synopsis
  • Lymphatic metastasis is a frequent issue in nasopharyngeal carcinoma (NPC), a type of cancer associated with the Epstein-Barr virus (EBV), though the virus's exact role in metastasis was not well understood.
  • * The study found that EBV promotes lymph node (LN) metastasis in NPC by enhancing lymphangiogenesis through the secretion of VEGF-C, with specific cellular mechanisms involving PHLPP1 and hyperactivity of AKT/HIF1a.
  • * Targeting this EBV/VEGF-C pathway could provide new treatment strategies for NPC patients experiencing lymphatic spread, as evidenced by the analysis of various proteins associated with this process in clinical specimens.*
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  • A 60-year-old man experienced numbness and weakness in his right arm, leading to the discovery of a mass in his right lung that was diagnosed as primary lung adenocarcinoma.
  • The cancer was staged as IIIA and positive for programmed death ligand 1, but negative for certain genetic mutations; he was treated with neoadjuvant tislelizumab and chemotherapy.
  • Post-treatment, the patient showed significant tumor shrinkage (71%) and achieved a complete pathological response, with no circulating tumor cells detected after the first round of adjuvant therapy.
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Fluorescence anisotropy (FA) has been widely applied for detecting and monitoring special targets in life sciences. However, matrix autofluorescence restricted its further application in complex biological samples. Herein, we report a near-infrared-II (NIR-II) FA strategy for detecting adenosine triphosphate (ATP) in human serum samples and breast cancer cell lysate, which employed NIR-II fluorescent AgSe quantum dots (QDs) as tags to reduce matrix autofluorescence effect and applied graphene oxide (GO) to enhance fluorescence anisotropy signals.

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The CsCO-catalyzed reaction of 2-oxindoles with enones affords 2,2-disubstituted indolin-3-ones through domino "Michael addition-oxidation-ring-cleavage-C-N coupling" process. O acts as the sole oxidant to accomplish the oxidative process. The indolin-3-ones can be further transformed to pyridazine, azirdine-fused 3-oxindoles, 4-quinolone derivatives easily.

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A convenient approach for the synthesis of 1,4-diketones bearing an amino group has been developed through the K2CO3-catalyzed reaction of 2-oxindoles with enones with the assistance of atmospheric O2 via sequential Michael addition-oxidation-ring-cleavage process. The further intramolecular reaction leads to the formation of benzoazepinone, quinoline, and 3-oxindole derivatives.

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